its etiopathogenesis remain unclear, partially because of the genetic heterogeneity of scoliosis and the lack of appropriate model systems. Recently, the development of efficient gene editing
We investigated whether inhibition of cell proliferation was associated with inhibition of luciferase expression in MITO-Luc/GFP1zebrafish model. To this aim, a pool of 24 hpf embryos was treated with a sub-lethal dose of a well-known anti-proliferative drug, 5Fluoro Uracil (5FU)53. We acqui...
the Zebrafish model has proved to be an important tool in the studies of infections and immunological responses. This model has the advantage of having OECD-specific guidelines for safety evaluation of chemical compounds (acute toxicity), which is performed within 96 h [65]. In addition, obser...
In the present review, we aim to illustrate the eminent progress that zebrafish propounds in order to comprehend the pathological mechanisms of AD. It can be envisaged that zebrafish model has emerged as an interesting tool for strategic study of AD203. The gap between drug discovery based on ...
Idiopathic scoliosis (IS) affects 3% of children worldwide, yet the mechanisms underlying this spinal deformity remain unknown. Here we show that ptk7 mutant zebrafish, a faithful developmental model of IS, exhibit defects in ependymal cell cilia development and cerebrospinal fluid (CSF) flow. Trans...
We have developed a zebrafish model for DIO and validated the model by several methods, including biochemical and histological analyses, diet therapies and DNA microarray analysis of visceral AT with comparison to those of mammalian obesity. These studies revealed that DIO zebrafish and obese mammals ...
In the last twenty years, research using zebrafish as a model organism has increased immensely. With the many advantages that zebrafish offer such as high
Therefore, we developed a zebrafish model to study the renal involvement of HPS proteins in proteinuric kidney disease. Remarkably, knockdown of HPS genes in zebrafish causes glomerular injury with edema, proteinuria and structural changes of the glomerular filtration barrier. Moreover, reduced ...
Zebrafish:An Alternative Animal Model for Safety Pharmacology Zebrafish as a vertebrate animal model is increasingly applied for both in vivo drug pharmacology and for preclinical safety evaluation.Numerous studies have confirmed that mammalian and zebrafish are highly similar in physiology,develop... Chun...
The zebrafish model organism is increasingly used for assessing drug toxicity and safety and numerous studies confirm that mammalian and zebrafish toxicity profiles are strikingly similar. This transparent vertebrate offers several compelling experimental advantages, including convenient drug delivery and low co...