【摘要】锌指E -盒结合同源异形盒1-反义链1(ZEB1-AS1)属于长链非编码RNA (Lnc RNA)家族，是E 盒锌指蛋白1基因(ZEB1)的反义蛋白产物，可通过上调ZEB1的活性促进肿瘤浸润、转移，其表达的失调与多种肿瘤的发生、发展密切相关，有望成为肿瘤治疗的重要分子靶点。近年来，大量研究表明ZEB1-AS1及其相关基因ZEB1可通过...
Cell ProliferationLi J, Li Z, Leng K, Xu Y, Ji D, Huang L, Cui Y and Jiang X. ZEB1-AS1: a crucial cancer-related long non-coding RNA. Cell Prolif 2018; 51.Li J, Li Z, Leng K, et al. ZEB1-AS1: A crucial cancer-related long non-coding RNA. Cell Proliferation. 2018;51....
OS)、无进展生存期(progression-free survival,RFS)、高肿瘤分期(high tumor stage,HTS)以及淋巴结转移(lymph node metastasis,LNM)密切相关,说明lncRNA ZEB1-AS1有望成为预测肿瘤患者预后的生物标志物。
综上所述,ZEB1-AS1敲低可抑制B-NHL细胞增殖和促进细胞凋亡,ZEB1-AS1敲低协同Dox作用后的杀伤作用更明显,lncRNA ZEB1-AS1可能作为DLBCL潜在的生物标志物,以ZEB1-AS1为节点构建的ceRNA调控网络,可能是DLBCL重要的调控机制和诊疗靶点。
ZEB1-AS1TRPML1LysosomeThe prevalence of cardiovascular diseases (CVDs) has increased markedly as the world population has aged. Long non-coding RNAs (lncRNAs) have been reported as novel regulators in diverse pathophysiological conditions. Here, we performed RNA sequencing (RNA-seq) and observed that...
The interaction between miR-133a-3p and LPAR3, EGFR and ZEB1- AS1 was testified through using RNA pull down and luciferase reporter assays. Results: LPAR3 and EGFR were expressed at high levels in TC tissues and cell lines. Besides, both LPAR3 and EGFR could promote TC cell growth. ...
本研究旨在发现lncRNA Zeb1-AS1和Zeb1在骨性关节炎软骨细胞和正常软骨细胞中表达情况。方法:原代细胞培养技术,培育膝骨关节炎和正常膝软骨细胞。应用实时荧光定量核酸检测技术(qPCR),蛋白免疫印记技术(WB)分别检测骨关节炎软骨细胞和正常软骨细胞中的Zeb1-AS1和Zeb1的表达水平。结果:Zeb1-AS1和Zeb1在膝骨关节炎细胞中...
Long non-coding RNA ZEB1-AS1 regulates miR-200b/FSCN1 signaling and enhances migration and invasion induced by TGF-β1 in bladder cancer cells Ruxu Gao, Naiwen Zhang, Jianyu Yang, Yuyan Zhu, Zhe Zhang, Jianfeng Wang, Xiaolong Xu, Zeliang Li, Xiankui Liu, Zhenhua Li, Jun...
目的 当前关于ZEB1-AS1对肺腺癌血管生成的作用机制尚未明确.文中研究肿瘤相关性成纤维细胞中长链非编码RNALncRNA ZEB1-AS1的表达及其对肺腺癌细胞和血管内皮细胞功能的影响. 方法 采取RT-PCR检测ZEB1-AS1在肺腺癌组织与配对癌旁正常组织以及肺腺癌细胞系,肿瘤相关性成纤维细胞(CAFs)以及配对的正常成纤维细胞中的表达情...