Abbreviations: ZBP1(L): long isoform; ZBP1(S): short isoform; CTR: control; PDs: population doublings. Source data Extended Data Fig. 5 Induction of ISGs requires both Zα2 and RHIM1 domains of ZBP1. a, Schematic representation of the human ZBP1 mutants. Asterisk represents amino-acid ...
ZBP1 is an IFN-inducible protein that binds double- stranded Z-form DNA and RNA31,32. Although impli- cated as a sensor of cytosolic DNA with the potential to trigger an IFN response15, any central role as a DNA sensor has long been questioned18. ZBP1 contains tandem amino-terminal Z...
ZBP1 is an IFN-inducible protein that binds double- stranded Z-form DNA and RNA31,32. Although impli- cated as a sensor of cytosolic DNA with the potential to trigger an IFN response15, any central role as a DNA sensor has long been questioned18. ZBP1 contains tandem amino-terminal Z...
ZBP1 is an interferon (IFN)-induced nucleic acid (NA) sensor that senses unusual Z-form NA (Z-NA) to promote cell death and inflammation. However, the mechanisms that dampen ZBP1 activation to fine-tune inflammatory responses are unclear. Here, we characterize a short isoform of ZBP1 (ref...
YB-1 recruitment to the IRES. Of note, a mutated form of the c-Myc IRES which enhances IRES activity and results in an increased expression of c-Myc was identified in a cohort of multiplemyelomapatients[44]. It was later determined that YB-1 and PTB, another c-Myc ITAFs, bind more ...
ITY Is a polyester / polyester composite fiber form. There are two production methods: one is made by combining FDY and POY as raw materials on flat draw machine, and the other is made by adding intermingle points on texturizing machine w...
ZBP1 is an IFN-inducible protein that senses viral and endogenous Z-form nucleic acids via its Zα domains and triggers cell death to induce antiviral immunity, but also causes tissue damage and inflammation20,21,22,23,24,25,26,27. Previous studies have shown that ZBP1 causes cell death ...
Collectively, these findings demonstrate that IAV triggers necroptosis without need for concurrent suppression of apoptosis and call into question the prevalent idea in the field that necroptosis is a backup form of cell death that is only activated when apoptosis pathways are disabled. Importantly, ...
ZBP1 is an interferon (IFN)-induced nucleic acid (NA) sensor that senses unusual Z-form NA (Z-NA) to promote cell death and inflammation. However, the mechanisms that dampen ZBP1 activation to fine-tune inflammatory responses are unclear. Here, we characterize a short isoform of ZBP1 (...
Z-DNA binding protein 1 (ZBP1) stabilizes Z-form mtDNA and nucleates a cytosolic complex containing cGAS, RIPK1, and RIPK3 to sustain STAT1 phosphorylation and type I interferon (IFN-I) signaling. Elevated Z-form mtDNA, ZBP1 expression, and IFN-I signaling are observed in cardiomyocytes ...