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ZBP1 forms filaments at mitochondrial membranes To decipher the mechanism of ZBP1 signalling, we performed immunostaining of ZBP1 in crisis cells, which revealed filamentous structures in the cytoplasm (Fig. 4a). ZBP1 lacking functional Zα2 and RHIM1 domains did not form these filaments, whereas...
However, the occurrence of non-apoptotic forms of cell death in the later stages of infection has recently captured more attention. Through TEM and LDH assays, we confirmed for the first time that necroptosis occurred in PTCs during the later stages of PPV infection. We also observed an up...
PANoptosis是一种新兴的受控细胞死亡(RCD)形式,其特征是同时激活焦亡、凋亡和坏死信号,不仅参与炎症性疾病的病理过程,而且在抵抗病原体感染方面也起着关键作用。靶向PANoptosis是治疗相关炎症性疾病的一种有前景的治疗策略,但寻找PANoptosis抑制剂的需求仍未得到满足。黄芩苷是一种从黄芩中分离出的活性黄酮,黄芩是一种传统...
ZBP1 forms homotypic interactions with the RHIM domain-containing proteins RIPK1 and RIPK3 to mediate NF-κB activation and innate immune signaling, as well as promote RIPK3-MLKL-dependent necroptosis.16,97,98,99,100 However, MLKL-mediated cell death does not impact IFN-I responses in cells...
Subsequent investigations reveal that Zαβ could form condensates with liquid-liquid phase separation property upon HSV and IAV infections, while full-length ZBP1 forms amyloid-like puncta with or without infections. Furthermore, ZBP1 RHIM domains show typical amyloidal fibril characterizations and ...
Subsequent investigations reveal that Zαβ could form condensates with liquid-liquid phase separation property upon HSV and IAV infections, while full-length ZBP1 forms amyloid-like puncta with or without infections. Furthermore, ZBP1 RHIM domains show typical amyloidal fibril characterizations and ...
SMAUG2RBPuses a similar mechanism to maintain embryonic neural precursors in a stem cell state. This protein forms a complex with 4E-T to repress translation of the pro-neural mRNANanos1, sequestering it into P-body-like granules [25]. NANOS1 is an RBP that represses the translation of pro...
et al. AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature 597, 415–419 (2021). https://doi.org/10.1038/s41586-021-03875-8 Download citation Received17 March 2021 Accepted04 August 2021 Published01 September 2021 Issue Date16 September 2021 DOIhttps://...
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