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Zavegepant nasal spray (ZAVZPRET) is the first intranasal calcitonin gene-related peptide (CGRP) receptor antagonist approved in the USA for the acute treatment of migraine with or without aura in adults. It is a valuable option for these patients, particularly for those who prefer nonoral ...
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Objective: The objective is to review the pharmacology, efficacy, and safety of intranasal zavegepant in the acute treatment of migraine with or without aura. Data source: PubMed, Embase database, and ClinicalTrials.gov were searched using the following terms: Zavzpret, Zavegepant, BHV-3500,...
However, further research is necessary to effectively assess Zavegepant's long-term efficacy, safety, tolerability, and drug-drug interactions.Larik, Muhammad OmarDow International Medical CollegeIftekhar, Muhammad AshhalJinnah Sindh Med UnivSyed, Bilal UlhassanAnsari, OmemaAnsari, Mozaena...
The objective of this study was to evaluate the safety and tolerability of zavegepant in the acute treatment of migraine under repeated, as-needed dosing for up to one year. Methods: This phase 2/3, one-year open-label safety study of zavegepant 10 mg nasal spray for the acute ...
Interpretation: Zavegepant 10 mg nasal spray was efficacious in the acute treatment of migraine, with favourable tolerability and safety profiles. Additional trials are needed to establish the long-term safety and consistency of effect across attacks. Funding: Biohaven Pharmaceuticals....
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Zavegepant is a novel gepant administered as a nasal spray approved in the United States at a 10 mg dose for the acute treatment of migraine with or without aura in adults. The cardiovascular safety of zavegepant nasal spray was assessed in both single‐ascending dose (SAD...