3. Chen J, Sathiaseelan V, Moore A, et al. ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia. Blood. 2021;137(26):3629–3640. 4. Burger J, O'Brien S. Evolution of...
Gene Typeprotein-coding gene Uniprot IDP43403 Pathway/LibraryKinases Library Gene SummaryThis gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T...
protein-coding gene 同源简称(alias symbol) ZAP-70|STD 基因家族代码(gene_family_id) 741[HGNC][GenScript] omim代码 176947 entrez码 7535[Vega] ensembl基因码 ENSG00000115085[Ensembl] 基因家族(gene family) SH2 domain containing refseq数据库代号 ...
基因序列:NCBI_Gene:22637 蛋白序列: UniprotKB:P43404 UniprotKB:A0A087WQ05 小鼠Mouse Zap70 靶点分子功能(预测) Enables ATP binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Acts upstream of or within several processes, including T cell selection; positive ...
This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene....
Gene Name: zap70 Protein Name: nan Human Gene Id: 7535 Swiss-Prot: P43403 Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Source: Monoclonal, Mouse Dilution: WB: 1:1000 PurIF:ication: The antibody was affinity-purIF:ied from mouse ascites by affinity...
(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several ...
See Invitae tests that include this gene. Alias ADMIO2; IMD48; SRK; STCD; STD; TZK; ZAP-70 Associated disorders The ZAP70 gene is associated with autosomal recessive combined immunodeficiency due to ZAP70 deficiency (MedGen UID: 376544). Ordering information Turnaround time: 10–21 calendar...
The results of this study show that ZAP-70 is required for antigen-driven negative selection of thymocytes.Tak W. MakJosef PenningerJohn RoderJanet RossantMary SaundersThe Gene Knockout FactsBook
如果需要筛选Cas9成功诱导双链断裂的细胞,推荐用 Zap-70 HDR质粒(m) (sc-423755-HDR) 共转染。 转染后,基因敲除效率可以用抗体:ZAP-70: sc-32760,通过WB, IF或者IHC分析 看到协议线上. 下载 说明书 实验流程 快捷链接 相关产品 订购信息 产品名称产品编号规格价格数量收藏夹 ...