However, it is likely that not all the ROS1 fusion variants described in other solid malignances such as inflammatory fibroblastic tumor (IMT) (YWHAE-ROS1) [38], anaplastic large cell lymphoma (NFkB2-ROS1, NCOR-ROS1) [39], and in pigmented spindle cell nevus/Spitz nevus (CLIP1-ROS1...
Our previous studies demonstrated transforming properties and diagnostic relevance of the fusion oncoprotein YWHAE鈥揘UTM2 in high-grade endometrial stromal sarcoma (HG-ESS) and showed that cyclin D1 is a diagnostic biomarker in these HG-ESS. However, YWHAE鈥揘UTM2 mechanisms of oncogenesis and ...
Endometrial stromal sarcoma (ESS) is the second most common subtype of uterine mesenchymal cancer, after leiomyosarcoma, and oncogenic fusion proteins are found in many ESS. Our previous studies demonstrated transforming properties and diagnostic relevance of the fusion oncoprotein YWHAE–NUTM2 in high-...
Introduction: High-grade endometrial stromal sarcoma is characterized by high Cyclin D1 expression and YWHAE-FAM22 genetic fusion. A rare case of myxoid high-grade endometrial stromal sarcoma with fertility-sparing surgery is des...
ZytoLight SPEC FOXO1/PAX3 Dual Color Single Fusion Probe ZytoLight SPEC FOXO1/PAX7 Dual Color Single Fusion Probe ZytoLight SPEC FOXO1/PAX3 TriCheck Probe ZytoLight SPEC FUS Dual Color Break Apart Probe ZytoLight SPEC GATA2/MECOM Dual Color Dual Fusion Probe ZytoLight SPEC IGL Dual ...
Fusion protein corresponding to C terminal 254 amino acids of human YWHAE 技术规格 Full name: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Synonyms: MDS, MDCR, KCIP-1, 14-3-3E Swissprot: P62258 ...
In the course of the procedure of differential diagnoses, we included fluorescence in situ hybridization analysis for detection of a FAM22B-YWHAE fusion gene resulting from t(10;17)(q22;p13), recently reported in a series of endometrial stromal sarcoma, and unexpectedly identified breakages at ...
YWHAE-rearranged high-grade endometrial stromal sarcoma (HG-ESS) is a rare, recently defined uterine sarcoma harboring t(10;17)(q22;p13) resulting in YWHAE-NUTM2A/B fusion. Chemotherapy sensitivity of metastatic YWHAE-rearranged HG-ESS is unknown. We reviewed the response to chemotherapy in ...
13: A Case of Rare Kidney Tumor Harboring YWHAE-NUTM2 Infusion in a 3-Month- Old MaleBackground: Clear cell sarcoma of the kidney (CCSK) is the second most common malignant renal tumor in children after Wilms tumor. CCSK commonly accounts for 3% - 5% of all pediatric renal tumors and ...
Recently, a fusion between the YWHAE and FAM22A/B genes subsequent to a t(10;17) (q22;p13) has been described in endometrial sarcomas with high-grade histology. We examined YWHAE rearrangements by FISH break-apart and RT-PCR in a series of 27 undifferentiated uterine stromal sarcoma without...