is a sequence between the unstructured N-terminal and C-terminal [6] (Fig.1B). Among DF1, DF2 and DF3 proteins, 86% of the corresponding YTH structural domain had the same sequence. The crystal structure of YTH family proteins showed us a new understanding...
On the basis of their primary sequences and domain organizations, these five human YTH domain-containing proteins can be classified into three categories: YTHDC1 (DC1 family), YTHDC2 (DC2 family), and YTHDF1–3 (DF family) (Figure 2A). YTHDC1 is a nuclear protein involved in gene ...
Our study also provides a platform for further investigations of addi- tional YTH-m6A-RNA complex structures, which would reveal molecular mechanisms for specific recognition of m6A-RNA by YTHDF2 and other YTH family proteins. The coordinate and structure factor for the YTHYTHDF2 structure have ...