Yolk sac erythromyeloid progenitors sustain erythropoiesis throughout embryonic lifedoi:10.1101/2020.02.27.968230Francisca Soares-da-SilvaOdile Burlen-DefranouxRamy ElsaidLorea IturriLaina FreyerOdile SismeiroPerpétua Pinto-do-Elisa Gomez-PerdigueroAna Cumano...
Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely understood. Here we show the early ...
The primary yolk sac, or primary umbilical vesicle, forms from proliferating hypoblast cells after implantation. The inner cell mass becomes a bilaminar embryonic disc as it divides into the hypoblast, which forms the yolk sac, and the epiblast, which forms the amnion. The yolk sac and amnion ...
The second wave includes fetal liver monocytes (FL-MOs), generated in the fetal liver from E12.5 onward from late yolk sac-derived erythro-myeloid progenitors. The third wave comes from hematopoietic stem cells that colonize the bone marrow from E17.5 onward and produce bone marrow monocytes (...
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors 2015, Nature Monocytes and macrophages: Developmental pathways and tissue homeostasis 2014, Nature Reviews Immunology Microglia and brain macrophages in the molecular age: From origin to neuropsychiatric disease 2014, Nature...
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Most haematopoietic cells renew from adult haematopoietic stem cells (HSCs), however, macrophages in adult tissues can self-maintain independently of HSCs. Progenitors with macrophage potential in vitro have been describ...
Perdiguero EG, Klapproth K, Schulz C, Busch K, Azzoni E, Crozet L, et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature (2014) 518(7540):547-51. doi:10.1038/nature13989Perdiguero, E.G., Klapproth, K., Schulz, C., Busch, K., Azzoni...
Specified prior to and during the formation of these initial HSCs are thousands of yolk sac-derived erythro-myeloid progenitors (EMPs). EMPs ensure embryonic survival prior to the establishment of a permanent hematopoietic system, and provide subsets of long-lived tissue macrophages. While an ...
Rodewald. 2015.Tissue-resident macrophages originate from yolk-sac- derived erythro-myeloid progenitors. Nature. 518:547-551. http://dx .doi.org/10.1038/nature13989Gomez Perdiguero E, Klapproth K, Schulz C, et al. Tissue-resident macrophages originate from yolk-sac-...
In contrast, EGFP(+) erythro-myeloid progenitors, immature and intermediate differentiation stages of YS erythroid and myeloid cell lineages, were expanded. Tie2-Cre;N1ICD YS had reduced numbers of CD41(++) megakaryocytes, and these produced reduced below-normal numbers of immature colonies in ...