YM-58483CAS:223499-30-7产品活性:作为选择性SOCE阻滞剂,YM-58483在Jurkat T细胞中抑制anti-CD3抗体所诱导的持续性钙离子流入。它抑制CRAC、TRPC3和TRPC5通道、促进TRPM4通道,抑制细胞因子的产生(IL-2, IL-4, IL-5, IFN-γ等)及T细胞的增殖。通过抑制NF-AT的激活,YM-58483可抑制MLR相关的脾细胞增殖[1]。
View and buy high purity YM 58483. Inhibitor of SOCE in non-excitable cells. Cited in 10 publications.
YM-58483 (BTP2) 是一种 CRAC channels 抑制剂,能够抑制 Ca2+ 信号。 产品性质 英文别名(English Synonym) YM-58483 中文名称(Chinese Name) / 靶点(Target) SOCE 通路(Pathway) Membrane Transporter/Ion Channel CAS号(CAS NO.) 223499-30-7 分子式(Formula) ...
YM-58483/BTP2 is a blocker of store-operated Ca2+ entry (SOCE), which regulates the activation of non-excitable cells such as lymphocytes. YM-58483 has been reported to inhibit cytokine production and proliferation in T cells, and to be useful as a probable medicinal candidate for treatment ...