the immune checkpoint PD-1/PD-L1 inhibitors Nivolumab and Pembrolizumab are FDA-approved for patients with recurrent or metastatic HNC and, interestingly, YBX1 has been shown to regulate the expression of PD-L1 within an immunosuppressive microenvironment50, establishing this factor as an important th...
Genetic depletion or pharmacological inhibition of Chek2 with blood-brain-barrier permeable drugs that are in the clinical trials, in combination with PD-1/PD-L1 blockade, led to survival benefit in preclinical glioma models. Analysis of human GBMs demonstrated that Chek2 expression is inversely ...
KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway. Cell Death Differ. 2021;28(4):1284–300. Article PubMed CAS Google Scholar Sheng C, Qiu J, He Z, Wang H, Wang Q, Guo Z, et al. Suppression of...
Targeting the YB-1/PD-L1 Axis to Enhance Chemotherapy and Antitumor Immunity. Cancer Immunol Res. 2019;7:1135–47. L i et al. Holistic Integrative Oncology (2023) 2:16 Page 11 of 11 53. Ohga T, Koike K, Ono M, et al. Role of the human Y box-binding protein YB-1 in ...
The immunosuppressive microenvironment caused by several intrinsic and extrinsic mechanism has brought great challenges to the immunotherapy of pancreatic cancer. We identified GFPT2, the key enzyme in hexosamine biosynthesis pathway (HBP), as an immune-related prognostic gene in pancreatic cancer using ...
Within the nucleus, YBX1 binds to the promoter sequences of PD-L1, an immune checkpoint protein, thereby boosting its transcription [109]. Consequently, this triggers PD-L1-mediated apoptosis of CD8+ T cells and upregulates immunosuppressive molecules like IL-10 and TGF-β. YBX1 also ...
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