m5C modification promotes YBX1 phase separation, which upregulates E2F1 expression. In ovarian cancer, NSUN2 and YBX1 are amplified and upregulated, and higher expression of NSUN2 and YBX1 predicts a worse prognosis for ovarian cancer patients. Moreover, E2F1 transcriptionally regulates the ...
Mechanistically, YBX1 recruited PABPC1 protein by recognizing the m5C modification in CHD3 mRNA to maintain mRNA stability and protein expression. Chromatin remodeling and HR repair capacity were therefore promoted. YBX1 might be a novel target for reversing platinum resistance. 2. Material and ...
The Y box binding protein 1 (YBOX1, also known as YBX1) is a multifunctional DNA- and RNA-binding protein with an evolutionarily ancient and conserved cold shock domain [19,20,21,22]. YBX1 is mainly distributed in the cytoplasm, but can also shuttle in the nucleus and cytoplasm. Abnorm...
In addition, YBX1 can function as a reader of RNA 5-methylcytosine (m5C) and stabilize mRNA through the indole ring of W65 in its CSD.36, 37 However, the YBX1-W65A mutant successfully rescued the phenotypes of YBX1-deficient leukemia cells, suggesting that the function of YBX1 as an ...
m5C modificationYBX1BGLAPOsteogenic differentiationOsteoporosis is a chronic metabolic bone disease that is prone to fractures. Isoimperatorin (ISO) has been shown to alleviate the bone loss in ovariectomized (OVX) rats. The aim of this study was to investigate the effect and the mechanism of ISO...
Here, we show that the m5C reader Ybx1 is highly expressed in the developing mouse hippocampus in the central nervous system (CNS). Conditional knockout of Ybx1 in the dentate gyrus (DG) decreases mossy fiber growth and affects short-term memory. In the peripheral nervous system (PNS),...
To our knowledge, this is the first report demonstrating that the interaction between host m5C reader YBX1 and HCV RNA m5C methylation facilitates viral replication. Therefore, hepatic-YBX1 knockdown holds promise as a potential host-directed strategy for HCV therapy.Zhu-Li Li...
Jeffrey B. KoppNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD .Zixuan FengShengjing Hospital of China Medical University, Shenyang, China;Feifei MiaoShengjing Hospital of China Medical University, Shenyang, China;Congcong Jiao...
YBX1 alleviates ferroptosis in osteoporosis via the ATF4/FSP1 axis in an m5C mannerdoi:10.1186/s13018-024-05119-7OsteoporosisFerroptosisY-box binding protein 1Activating transcription factor 4Ferroptosis suppressor protein 1Interactions between RNA-binding proteins and RNA regulate RNA transcription during...
Overexpression of NSUN2 resulted in gefitinib resistance and tumor recurrence, while genetic inhibition of NSUN2 led to tumor regression and overcame intrinsic resistance to gefitinibin vitroandin vivo. Integrated RNA-seq and m5C-BisSeq analyses identified quiescin sulfhydryl oxidase 1 (QSOX1) as a...