In our current study, we demonstrate that the membrane receptor CXCR7 (C-X-C chemokine receptor 7) is an important modulator of the Hippo/YAP axis. The activation of CXCR7 could stimulate gastric cancer cell progression through the Hippo/YAP axis in vitro and in vivo, while pharmaceutical in...
Sublethal cell damage can trigger senescence, a complex adaptive program characterized by growth arrest, resistance to apoptosis and a senescence-associated secretory phenotype (SASP). Here, a whole-genome CRISPR knockout screen revealed that proteins in
8). In addition, our studies implicate a low dose of VP as a potential strategy to treat clinic AKI patients at risk for developing CKD. Nevertheless, the mechanism of YAP persistent activation in maladaptive-repaired tubular epitheliums and how to appropriately intervene in YAP overactivation ...
Lai D, Ho KC, Hao Y and Yang X: Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res. 71:2728–2738. 2011.View Article:Google Scholar:PubMed/NCBI ...
Surprisingly, the p5353,54 TAD2 mutant behaves as a “super-tumor suppressor,” with an enhanced capacity to both suppress pancreatic cancer and transactivate select p53 target genes, including Ptpn14. Ptpn14 encodes a negative regulator of the Yap oncoprotein and is necessary and sufficient for ...
Targeting cancer stem cells is critical for suppressing cancer progression and recurrence. Finding novel markers or related pathways could help eradicate or diagnose cancer in clinic. By constructing STARD13-correlated ceRNA 3′UTR stable overexpression
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balance between cell proliferation and apoptosis. Several researches have revealed that the Hippo-YAP signaling pathway can affect cell proliferation and apoptosis so as to participate in the development of tumor. This paper will review the effect and mechanism of Hippo-YAP signaling pathway in tumor...
Here, unexpectedly, we find that liquid–liquid phase separation, rather than nuclear localization, of recurrent patient-derived YAP fusions, YAP-MAMLD1 and C11ORF95-YAP, underlies ependymoma tumourigenesis from neural progenitor cells. Mutagenesis and chimaera assays demonstrate that an intrinsically ...
Many different organisms have the ability to regenerate, although the robustness, efficiency, and scope of this regeneration is varied. Invertebrates such as planarians and Hydra regenerate their entire body such that, when cut in half, each section forms an entire new organism1,2,3,4. At the...