rhoayap直肠癌蛋白预后临床 摘要II摘要目的:检测YAP及RhoA的表达情况,探讨二者在结直肠癌患者癌组织和癌旁组织石蜡切片中的表达差异性,并分析二者与患者其他临床特征以及预后的相关性。方法:1、收集2010年10月至2011年12月南昌大学第一附属医院50名结直肠癌患者的基本资料及临床病理资料及癌旁组织和癌组织的石蜡样本
•Inducible RHOA deletion in mice causes defects in intestinal structure and polarity•RHOA controls intestinal stem cell proliferation and Hippo signaling•Active YAP/EREG, as well as β-catenin, rescues ISC loss caused by RHOA deficiency•RHOA-YAP-EREG signaling mediates intestinal maintenance ...
另外,关键基因 RhoA可作为YAP上游调控分子,诱导YAP核易位,直接参与 YAP的激活[23]。因此,我们猜测 NASH 早期小鼠肝细胞中YAP活性增加参与调控肝细胞代谢过程可能与关键基因所在的信号通路有关。 综上所述,本实验初步阐明,NASH 早期肝细...
The role of YAP (Yes-associated protein 1) and MRTF-A (myocardin-related transcription factor A), two transcriptional co-activators regulated downstream of GPCRs (G protein-coupled receptors) and RhoA, in the growth of glioblastoma cells and in vivo glio
HFD饲喂YAP/TAZ缺陷的小鼠,促凋亡基因BIM表达下调,脂肪细胞凋亡减少。在分化的脂肪细胞中,TNF-α和IL-1β通过激活RhoA介导的肌动球蛋白收缩性促进YAP/TAZ转移,并通过激活c-Jun、JNK和AP-1增加YAP/TAZ介导的转录调控。数据表明,YAP/TAZ信号通路可能...
increases with the reconstruction of the cell cytoskeleton and transduces physical inputs to modulate nucleocytoplasmic YAP shuttling [11]. This process requires Rho GTPases, myosin motors, RhoA/rho-associated coiled-coil-containing protein kinase (ROCK), and focal adhesion kinase (FAK) [12,13]....
J. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat. Immunol. 17, 914–921 (2016). Article CAS PubMed PubMed Central Google Scholar Shi, H., Murray, A. & Beutler, B. Reconstruction of the mouse inflammasome system in HEK293T cells. Bio...
Previous mathematical models that focused on YAP/TAZ signaling have treated the total amounts of key proteins such as FAK (19,30), RhoA (19), and YAP/TAZ (15) as constants. Notably, the degradation processes in these models often do not represent a loss of protein but a transition ...
DCLK1, RhoA and YAP activation following thrombin stimulation were inhibited by U0126 (ERK inhibitor). Moreover, DCLK1 and YAP siRNA inhibited κB-luciferase activity. Thrombin stimulated the recruitment of YAP and p65 to the NF-κB site of the IL-8/CXCL8 promoter and was inhibited by DCLK...
2023). RhoA is an essential component of the cytoskeleton and RhoA-mediated F-actin remodeling serves a crucial role in regulating Yap (Xu et al. 2012). BAPTA-AM, a Ca2+ channel blocker, restricted intracellular Ca2+ influx, which limited cytoskeletal aggregation, RhoA-mediated F-actin ...