陈昕教授通过“Molecular crosstalk between beta-catenin and Yap during cholangiocarcinoma development”专题,对肿瘤学基础研究的科研思路进行了探讨。陈昕教授及其团队主要从事肝癌生长过程中分子遗传学和信号通路研究,重点聚焦在Hippo/YAP/TAZ通...
Mech anical strain induces E-cadherin-dependent Yap1 and beta- catenin activation to drive cell cycle entry[ J]. Science ,2015,348 (6238) : 1024-1027.Benham-Pyle BW, Pruitt BL & Nelson WJ (2015) Cell adhesion. Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation...
and detection of the protein levels of ZDHHC12 and YAP1 in different tissue samples was carried out.Results:The analysis results of TCGA database and GTEx database showed that the expression of ZDHHC12 was significantly higher
Mechanical strain induces E-cadherin-dependent Yap1 and beta-catenin activation to drive cell cycle entry. Science 348, 1024–1027 (2015). Article CAS ADS PubMed PubMed Central Google Scholar Gilkes, D. M., Bajpai, S., Chaturvedi, P., Wirtz, D. & Semenza, G. L. Hypoxia-inducible ...
YAP/TAZ作为破坏复合物的组成部分,并以类似于β-catenin的方式受Wnt调节。然而,最近的一项研究表明,Wnt可通过Frizzled(一种类似于GPCR的Wnt受体)、Gα12/13、Rho GTPases和LATS1/2来激活YAP/TAZ。此外,作为SAV1和LATS1的支架蛋白,Apc的缺失可导致YAP的激活和肿瘤的发生。当然,可能还需要更多的研究来验证Wnt对...
.nf2基因的编码蛋白merlin是yap1信号通路的上游负调控子.在nf2突变型脑膜瘤中,由nf2基因失活造成的merlin蛋白缺失常常导致yap1基因的过表达并引起其靶向调控基因的过度转录,并进一步引起下游通路(如hippo,pi3k/akt和wnt/β-catenin信号通路)信号的异常增益 [10] . yap1是一种重要的转录共激活因子,在生理条件下它...
We previously reported that YAP1 is a part of the β-catenin signaling axis in CAFs that controls CAF behaviors and demonstrated that loss of either of them is detrimental to CAF function [6, 17, 27]. In this study, two mouse models carrying either YAP1-deficient CAFs or YAP1-...
Benham-Pyle, B. W., Pruitt, B. L. & Nelson, W. J. Cell adhesion. Mechanical strain induces E-cadherin-dependent Yap1 and beta-catenin activation to drive cell cycle entry.Science348, 1024–1027 (2015). CASPubMedPubMed CentralGoogle Scholar ...
Interestingly, aspirin not only significantly inhibited the growth of TNBC cells, but also attenuated YAP and β-catenin expression by upregulating the E3 ubiquitin ligase β-TrCP to abolished docetaxel and vinorelbine resistance. The combination of aspirin and docetaxel or vinorelbine remarkably inhibited...
Beta-catenin, an essential effector of canonical Wnt signaling can directly interact with the YAP1 protein (Imajo et al., 2012). The exact mechanisms and the significance of the interaction between YAP1/Hippo and Wnt signaling pathways are very complex and even the functional outcome of this ...