Request a Y Maze The second protocol evaluates spatial learning with spontaneous alternation. For this protocol, the mouse is not familiarized with the maze first. Food is placed in both arms and all the doors remain open. When the mouse is placed at the bottom of the Y, it chooses an ...
This construction makes the Y-Maze ideal for the Continuous Alternation protocol. Modifications such as guillotine doors and escape tunnels can easily be added to the maze. The Y-Maze can also be adapted for investigation of spatial learning specifics in different animals and disease or ...
Using the natural exploratory behavior of mice, the spontaneous alternation y-maze can assess short-term spatial working memory. The protocol for y-maze testing is straightforward and requires minimal resources, as well as animal training and output. Therefore, it can be broadly applied to study ...
F. Y-maze spontaneous alteration test was conducted to examine the working memory of mice with different genotypes at 6 months of age. N =23-26 mice per genotype, mixed sex. G. Contextual fear condition‑ ing test (CFC) was conducted to examine the associative memory of mice with ...
During postnatal days 10–13 (PND 10–13) rat pups were exposed to a T-maze, one arm of which lead to the mother. One group of animals was allowed contact with the mother (rewarded—receiving expected reward (RER)), whereas the other was denied the expected reward (DER). High ...
have been developed for zebrafish, such as open field tank, black-white preference and t-maze tests16. Therefore, the zebrafish is an excellent animal model for drug development17, first-medicine screening18, and studies on social behaviour19. The NPY amino acid sequence is strictly conserved ...
d Left: acquisition phase of the Barnes maze test with improved performance for both groups in the first 4 training days (same cohort as (b), p > 0.05, Two-Way ANOVA, Sidak's); right: memory assessment on probe day 5 (Two-Way ANOVA, Tukey's); sex x genotype p = 0.01, Three-...
sttest.eRepresentative elevated plus maze (EPM) traces of non-stress and novelty stress groups. The gray shades indicate the closed arms.fPercentages of open-arm time in the EPM. Two-sided unpaired Student’sttest with Welch’s correction.gRepresentative open field test (OFT) traces of non-...
as determined by Student’s t test. (B) Ghrelin leads to increased NPY protein content, using an Enzyme-Linked Immunosorbent Assay, as described in Material and Methods. The results represent the mean ± SEM of three independents experiments and are expressed as the relative amount compared to...
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