非酒精性脂肪性肝病(NAFLD,现称MAFLD)是指除酒精和其他明确肝损伤因素外,所致的肝细胞内脂肪过度沉积为主要特征的临床病理综合征,早期通常无明显临床症状,随后可发展为非酒精性脂肪性肝炎(non-alcoholic steatohepatitis, NASH,现称MASH),即一种以炎症和纤维化为特征的...
276,277,278 X-box binding protein 1 (XBP1) is a key transcription factor in the IRE1a signaling branch and is spliced by endoribonuclease and IRE1a to regulate protein folding, trafficking, and secretion, thus enhancing cell survival and ER homeostasis under ER stress.279 Researchers found ...
CRP, C-reactive protein; FIB4, fibrosis-4 index; IGFBP6, insulin-like growth factor binding protein 6; NFS, NAFLD fibrosis score; PLTs, platelets. A further subgroup analysis comparing patients with differentially pronounced losses in body fat percentage (=<13.5% or >13.5%) revealed lower ...
The inhibition of heat shock protein 90 beta (HSP90β) facilitates the ubiquitination and proteasomal degradation of mature sterol regulatory element-binding proteins (SREBPs), leading to the amelioration of lipid metabolism disorders in patients with nonalcoholic fatty liver disease (NAFLD) and diet-...
Sterol regulatory element binding protein-1c SOD: Superoxide dismutase TC: Tholesterol TCM: Traditional Chinese Medicine TCS: Thiolated chitosan TG: Triglycerides TIMPs: Tissue inhibitors of MMPs WHO: World Health Organisation ZEB2: Zinc finger E-box binding homeobox 2 References Qin ...
Liver fibrosis, as a pathophysiological result of chronic liver injury, is the leading cause of mortality from chronic liver diseases (CLDs) worldwide. CLDs mainly include chronic infection with hepatitis virus, NAFLD, alcoholic liver diseases, and autoimmune liver diseases12,13. CLDs could progress...
Sterol regulatory element binding protein-1c SOD: Superoxide dismutase TC: Tholesterol TCM: Traditional Chinese Medicine TCS: Thiolated chitosan TG: Triglycerides TIMPs: Tissue inhibitors of MMPs WHO: World Health Organisation ZEB2: Zinc finger E-box binding homeobox 2 ...