Y-27632 是口服有效的,ATP 竞争性的 ROCK-I 和 ROCK-II 抑制剂,Ki 分别为 220 nM 和 300 nM。Y-27632 减弱阿霉素诱导的人心脏干细胞凋亡 (apoptosis)。Y-27632 还抑制分离诱导的小鼠前列腺干/祖细胞凋亡。Y-27632 通过上皮-间充质过渡样调节引发人诱导多能干细胞 (hIPSCs)
Rho 激酶抑制剂 Y-27632 对 C3H10T1/2 细胞增殖与成脂分化的作用[J]. 中国 生物化学与分子生物学报(Wang XL, Ji YT, Qu CQ. Effect of Rho kinases inhibitor Y-27632 on proliferation and adipogenic differentiation of mesenchymal stem cell C3H10T1/2[J]. Chin J Biochem Mol Biol), 2013, 29(7...
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 2000 May;57(5):976-83. [2]. Xue ZW, et al. Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of adult human adipose tissue-derived stem cells.Chin Med J ...
关键词:Y.27632;问充质干细胞;增殖;成脂分化;抑制IIAbstractAbstractObjective:Whenculturedmesenchymalstemcellswereinducedintoadipoeytesinvitro,thecellmorphologyhadadramaticchange.Fromtheinitialfusiformbecameroundandultimatelyledtoacircularcellfilledwithahugeintracellularlipiddroplets.Rhoki/lases(ROCK)couldregulateactin...
在保存液中添加Y-27632后,角膜缘上皮细胞的活性率显著提高,且角膜缘干细胞形成的克隆体积大,形态规则,至保存14天,克隆形成率仍明显高于对照组保存液。结论在角膜保存液中添加Y-27632可显著提高角膜保存效果,同时可维持角膜缘干细胞的活性及功能,因此可以作为角膜保存液的有效添加成分用于保存角膜。【关键词】角膜保存...
and main tai n th e c harac teri sti c s of s tem c el ls ,wh ic h is exp ec ted for tis su e en gi neerin g tooth as s eed cel ls . [ K ey words] Epithelial stem cell;3 T3 cell ;Conditioned culture media;Y27632 近 年来 ,组 织工 程 和细 胞重组技术开展牙再生 ...
Y-27632 is a cell-permeable, highly potent and selective inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). Y-27632 inhibits both ROCK1 (Ki =220 nM) and ROCK2 (Ki = 300 nM) by competing with ATP for binding to the catalytic site. (Davies et al., Ishizaki et...
Y-27632 是一种 ROCK-I 和 ROCK-II 抑制剂,具有口服有效性、ATP 竞争性。Y-27632 还抑制分离诱导的小鼠前列腺干或祖细胞凋亡。 规格价格库存数量 1 mg¥ 247现货 2 mg¥ 352现货 5 mg¥ 578现货 10 mg¥ 745现货 25 mg¥ 1,450现货 ...
Y27632 is a cell-permeable small molecule Rho-associated kinase (ROCK) inhibitor1. Y27632 has been found to prevent apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency2. This...
Rho激酶抑制剂Y27632促进人诱导多能干细胞来源原始神经上皮细胞向多巴胺能神经前体细胞的转化 参考文献：［1］Virani SS,Alonso A,Aparicio HJ,et al.Heart disease and stroke statistics-2021update:a report from the American heart association ［J ］.Circulation,2021,143(8):e254-743.［2］李天伦,张中,...