Y-27632 是一种 ROCK-I 和 ROCK-II 抑制剂,具有口服有效性、ATP 竞争性。Y-27632 还抑制分离诱导的小鼠前列腺干或祖细胞凋亡。 规格价格库存数量 1 mg¥ 247现货 2 mg¥ 352现货 5 mg¥ 578现货 10 mg¥ 745现货 25 mg¥ 1,450现货 ...
Y-27632 is a cell-permeable, highly potent and selective inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). Y-27632 inhibits both ROCK1 (Ki = 220 nM) and ROCK2 (Ki = 300 nM) by competing with ATP for binding to the catalytic site. (Davies et al., Ishizaki ...
将hiPSCs-NECs消化后,添加5 μmol/L Y27632的hiPSCs-NECs相比较未加Y27632的对照组,细胞解离后贴壁存活率明显增加,处于S期的细胞(P<0.01)与细胞活力显著提高(P<0.01),且凋亡率显著降低(P<0.05),持续诱导至第28天,细胞高表达DAPs特异性的标记物(TH、FOXA2、NURR1和Tuj1)。结论 添加Y27632(5 μmol/L)2...
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 2000 May;57(5):976-83. [2]. Xue ZW, et al. Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of adult human adipose tissue-derived stem cells.Chin Med J ...
MCE 国际站:Y-27632 产品活性:Y-27632 是一种ATP竞争性的 ROCK-I 和ROCK-II 抑制剂,Ki 分别为 220 nM 和 300 nM,Y-27632 通过上皮-间充质过渡样调节引发人的诱导多能干细胞 (hIPSCs) 选择性地分化为间胚层谱系。 研究领域:Cell Cycle/DNA Damage | TGF-beta/Smad | Stem Cell/Wnt 作用靶点:ROCK In...
Y27632 is a cell-permeable small molecule Rho-associated kinase (ROCK) inhibitor1. Y27632 has been found to prevent apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency2. This...
品牌: StemRD 型号: Y-01 规格: 1mg StemRD Y-01 Y-27632 产品编号 Y-01 | StemRD 产品描述 Y-27632, (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridine-4-yl) cyclohexane-carboxamid-2HCl, is a Rho-associated kinase (ROCK) inhibitor. Y27632 has been shown to prevent apoptosis as well as...
Y-27632 is a research tool with a wide variety of biological effects, mainly used in the field of stem cell research for maintenance and differentiation. Commonly used as 3D growth matrix component; also a component of brain organoid differentiation media. ...
英文名称 Y-27632 生化机理 Y-27632 是一种新型支气管扩张剂 ROCK 抑制剂。Y-27632 在人和兔组织中的 IC50 分别为 3.3±0.25 μM 和 2.8±0.2 μM。 储存温度 避光,-20°C储存,充氩 运输条件 超低温冰袋运输 作用类型 抑制剂 作用机制 蛋白激酶 C epsilon 抑制剂;蛋白激酶 N2 抑制剂;Rho 相关...
Y-27632, a ROCK inhibitor, delays senescence of putative murine salivary gland stem cells in cultureSmall moleculeRho-associated kinase inhibitorSenescenceSuspension cultureSalivary gland stem cellSalisphereA loss of functional salivary glands often occurs after radiotherapy for head and neck tumour, and ...