别名:Y 27632;Y-27632 产地:中国 品牌:爱必信(absin) 包装规格:5mg,10mg,50mg 货号:abs812864 是否进口:否 公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 抑制剂描述: 产品名称:Y-27632 产品别名:见爱必信官网 英文别名:Y-27632 靶...
Y-27632 是一种 ROCK-I 和 ROCK-II 抑制剂,具有口服有效性、ATP 竞争性。Y-27632 还抑制分离诱导的小鼠前列腺干或祖细胞凋亡。 规格价格库存数量 1 mg¥ 247现货 2 mg¥ 352现货 5 mg¥ 578现货 10 mg¥ 745现货 25 mg¥ 1,450现货 ...
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 2000 May;57(5):976-83. [2]. Xue ZW, et al. Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of adult human adipose tissue-derived stem cells.Chin Med J ...
Y-27632 (5 mg/kg, 10 mg/kg)处理实验组小鼠,与对照组(生理盐水组)相比,Y-27632明显延长肌肉痉挛的发作时间和阵挛性惊厥发作时间。[2] 参考文献 Xue ZW, et al. Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of adult human adipose tissue-derived stem cells. Chi...
Y-27632 prevents cell apoptosis, enhances survival and cloning efficiency of human pluripotent stem cells when they are dissociated to single cells, and improves the efficiency of embryoid body formation using the forced aggregation method. Storageat -20℃ in the dark for six months, avoid repeated...
Y-27632 is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. ...
Y-27632 is a cell-permeable, highly potent and selective inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). Y-27632 inhibits both ROCK1 (Ki = 220 nM) and ROCK2 (Ki = 300 nM) by competing with ATP for binding to the catalytic site. (Davies et al., Ishizaki ...
MCE 国际站:Y-27632 产品活性:Y-27632 是一种ATP竞争性的 ROCK-I 和ROCK-II 抑制剂,Ki 分别为 220 nM 和 300 nM,Y-27632 通过上皮-间充质过渡样调节引发人的诱导多能干细胞 (hIPSCs) 选择性地分化为间胚层谱系。 研究领域:Cell Cycle/DNA Damage | TGF-beta/Smad | Stem Cell/Wnt 作用靶点:ROCK In...
Y-27632 is a cell-permeable, highly potent and selective inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). Y-27632 inhibits both ROCK1 (Ki = 220 nM) and ROCK2 (Ki = 300 nM) by competing with ATP for binding to the catalytic site. (Davies et al., Ishizaki ...
Y-27632作用于PKC, cAMP依赖的蛋白激酶和 肌球蛋白轻链激酶(MLCK)几乎没有活性，Ki分别为26 μM, 25 μM, 和 > 250 μM。Y-27632通过选择性抑制Ca2+敏感化，而抑制多种兴奋剂而不是KCl，包括Phenylephrine, Histamine, Acetylcholine, Serotonin, Endothelin,和Thromboxane诱导的平滑肌收缩，IC50为0.3-1 μM。