Much of the recent literature on xylazine use in humans comes from case reports and review articles.#Related to widespread use in veterinary medicine and increasing circulation in illicit drug markets, there is a critical need for public awareness and additional clinical-based studies to further ...
Veterinarians usexylazineon cattle, horses, and cervidae (e.g., deer) animals as a sedative and pain reliever. According to FDA, “it is not safe for use in humans and may result in serious and life-threatening side effects that appear to be similar to those commonly associated with opioi...
pharmacodynamic drug interaction between xylazine, heroin and cocaine in humans is difficult to assess due to the lack of research in this area. However, the concomitant use of these drugs may potentiate or attenuate the effects of these drugs, which can lead to toxic effects. The health care ...
There are some medications that have been used to reverse xylazine's effects in animals, Zagorski said, but it would take significant time and research to make sure that those medications could be used in humans. One drug has been approved for human use, but only in neonates, so researchers...
The medication, xylazine, has been FDA-approved to use as an animal sedative and pain reliever. It has no approved use for humans and can cause "serious and life-threatening side effects that appear to be similar to those commonly associated with opioid use." ...
In addition to its sedating properties, xylazine can also cause severe skin ulcers in humans, regardless of route of use (e.g., injection, smoking, snorting) [2, 11]. The US Drug Enforcement Administration has identified fentanyl containing xylazine in 48 states, with 23% of powder fentanyl...
Not for use in horses intended for food. Avoid accidental administration to humans. Should such exposure occur, notify a physician immediately. Artificial respiration may be indicated. In Cervidae, occasional capture-associated deaths occur. Clinical trials reveal a mortality rate of approximately 3.5%...
These similar pharmacologic effects may create synergistic toxic effects in humans. Therefore, fatalities among drug users may increase due to the use of xylazine hydrochloride as an adulterant. Xylazine hydrochloride alone has proven harmful to humans and even more when it is combined with drugs ...
In humans, xylazine can induce an opioid-like toxidrome including hypotension, bradycardia, and respiratory depression eventually leading to death, and repeated exposure may also cause withdrawal symptoms and severe necrotic cutaneous ulcers leading to amputation [7]. Xylazine toxic doses range from ...
Research has shown xylazine is often added to illicit opioids, including fentanyl, and that xylazine has been increasingly detected in the illicit opioid supply. While some people knowingly use fentanyl and xylazine in combination, many people do not know if the drugs they plan to use contain fen...