(SRY) is the key genetic component, normally residing on the Y chromosome, that results in testicular development, testosterone production, and a male phenotype.81Ninety percent of these 46,XX men have SRY, which normally resides on the distal portion of Yp, translocated to the X chromosome ...
regardless of gonadal sex. AlthoughKdm6awas identified as an X-linked gene overexpressed in XX B cells, inhibition of its enzymatic activity did not affect mitogen-induced plasma cell differentiation or antibody production in a sex chromosome-dependent manner ex vivo. Enhanced humoral...
In humans, sexual differentiation is directed by SRY, a master regulatory gene located at the Y chromosome. This gene initiates the male pathway or represses the female pathway by regulating the transcription of downstream genes; however, the precise mechanisms by which SRY acts are largely unknown...
In humans, sexual differentiation is directed by SRY, a master regulatory gene located at the Y chromosome. This gene initiates the male pathway or represses the female pathway by regulating the transcription of downstream genes; however, the precise mechanisms by which SRY acts are largely unknown...
which likely influences serum lipid levels and adiposity. Our findings may have important ramifications for human health, particularly following menopause, when protective effects of female sex hormones are lost, and the effects of an XX sex chromosome genotype may contribute to pro-atherogenic lipid ...
It was noted only recently that the mammalian X/Y sex chromosome system originated late in our therian ancestors. The question is, what makes the X/Y sex chromosome system so special that it has replaced the original Z/W sex chromosome system? Two classes of genes are overrepresented on the...
The X chromosome, hemizygous in males, contains numerous genes important to immunological and hormonal function. Alterations in X-linked gene dosage are suspected to contribute to female predominance in autoimmunity. A powerful example of X-linked dosage involvement comes from theBXSBmurine lupus model...
The phenotypic expression and mode of inheritance of this disorder is compared to XX sex reversal in humans and other animals. 展开 关键词: Animals Dogs Ovary Testis X Chromosome Dog Diseases Pedigree Disorders of Sex Development Female Male ...
What makes organisms develop into males or females? If you thought, “XX=females and XY=males,” you’re right, but only to a certain extent; this system is predominant only in a few species, such as humans. Not all animals employ the Y chromosome—and the SRYgeneon it—from the m...
Surely this is true in humans as well, for which reason one would predict existence of mutations that would be manifested as ovarian failure and infertility in otherwise normal women. Other possibilities include interference with germ cell migration, abnormal connective tissue milieu, or gonadotropin ...