Xpert MTB-Host Response (MTB-HR) has reached WHO test targets for pulmonary tuberculosis (PTB) with high bacillary loads. Our aim was to investigate the contribution of MTB-HR as a non-sputum, near point-of-care (POC) method for diagnosis of other prioritized groups, where MTB detection ...
Because Xpert MTB/RIF Ultra is more effective than conventional TB diagnostic techniques are, it is now regarded as an emerging technology. The diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculosis was assessed in this systematic study. Methods We searched the PubMed, Cochrane, EMBASE, and...
Upfront Xpert MTB/RIF testing of presumptive PTB and presumptive DR-TB cases resulted in diagnosis of 79 and 12 rifampicin resistance cases, respectively. Positive predictive value (PPV) for rifampicin resistance detection was high (98%, CI 90.1–99.9), with no statistically significant variation ...
On the other hand, in an in silico model capturing the immunological environment of the brain, both low and high TNF-α levels were detrimental to the host, resulting in bacterial overgrowth (El-Kebir et al., 2013), suggesting that the host immunological response may play an essential role ...
Stroke, mediated by vasculitis, may occur despite adequate TB treatment and is a major contributor to long-term morbidity [13]. Our understanding of the host inflammatory response remains limited and effective therapy to modulate this process has yet to be established. Xpert MTB/Rif® ...
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METHODS. A prospective evaluation of the Cepheid GeneXpert Mycobacterium tuberculosis Host Response cartridge (Xpert-MTB-HR), a prototype blood-based host response mRNA signature assay, among individuals presenting with TB-like symptoms was performed in Pakistan and results were compared ...
Impact of Xpert MTB/RIF for TB Diagnosis in a Primary Care Clinic with High TB and HIV Prevalence in South Africa: A Pragmatic Randomised Trial.doi:10.1371/journal.pmed.1001760Bacterial diseasesInfectious diseasesMedicine and health sciences
Catching the Missing Million: Experiences in Enhancing TB & DR-TB Detection by Providing Upfront Xpert MTB/RIF Testing for People Living with HIV in India . 2015, PLoS ONE 10 ( 2 ): e0116721 doi: 10.1371/journal.pone.0116721 , Available: http://journals.plos.org/plosone/article?id=...
While testing multiple specimens can potentially contribute to higher proportion of laboratory confirmed paediatric TB cases, lack of high sensitivity tests adds to the diagnostic challenge. We describe here our experiences in piloting upfront Xpert MTB/RIF testing, for diagnosis of TB in paediatric ...