the importance of gene–gene and gene–environment interactions for disease susceptibility Alexey V Polonikov, Vladimir P Ivanov and Maria A Solodilova The aim of our pilot study was to evaluate the contribution
lung, and skin comes more and more into the center of interest in the field of xenobiotic metabolism studies (Gundert-Remy et al.2014). In 2007, we published a review on xenobiotic-metabolizing enzymes (XME) in the skin of man, rat, and pig (Oesch et al.2007). The...
xenobiotic‑metabolizing enzymes in skin models Klaus Golka1 Published online: 1 December 2015 © Springer-Verlag Berlin Heidelberg 2015 Recently, Franz Oesch and colleagues have published a comprehensive review about the xenobiotic-metabolizing activity in skin of rat, mouse, pig, guinea pi...
The present study examines the possible transfer of the active principle(s) of mace (aril of the plant Myristica fragrans ) through the transmammary route and its ability to modulate hepatic xenobiotic metabolizing enzymes in the F 1 progeny of mice. An aqueous suspension of mace at the dose ...
Activators of PPARalpha affect xenobiotic-metabolizing enzymes (XMEs) at different levels. At the genomic level, the expression of numerous cytochrome P450 (CYP) and phase II conjugating genes is altered in a species-distinct manner on treatment with PPARalpha activators. As a result of such ...
Transmammary exposure of suckling mouse pups to the oil from the tree, Santalum album, Linn. and its ability to modulate hepatic neonatal xenobiotic metabolizing enzymes was examined. Sandalwood oil, at the dose levels of 5 ul and 10 ul per animal per day, was fed by oral gavage to lactati...
The aryl hydrocarbon receptor (AHR) and NF-E2 p45-related factor (NRF2) are two distinct transcription factors involved in the regulation of drug-metabolizing enzymes. Increasing evidence from several studies implies that AHR and NRF2 have direct links, but the molecular mechanism remains unknown. ...