TDF-induced receptors (AhR2 and PXR) changed many genes involved in steroid metabolism, and subsequent disruptions in steroid homeostasis, which might be the key biological pathway in TDF reproductive toxicity. However, due to the different metabolic demands, the transcript profiles involved in ...
The term “xenobiotic” refers to any foreign substance or exogenous chemical appearing in a biological system that is extrinsic to the normal metabolism of that system. The “xeno” in xenobiotic comes from the Greek word “ξένος” (xenos) meaning foreigner or stranger, while “biotic...
Among others, these crosstalk mechanisms might explain the manifold effects of -catenin on hepatic drug metabolism. In this review, the current knowledge regarding the role of Wnt/-catenin signaling in the regulation of hepatic expression of glutathione S-transferases is presented. In addition, the...
Drug Metabolism ReviewsKong AN, Owuor E, Yu R, Hebbar V, Chen C, Hu R, et al .: Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab Rev 2001, 33 (3–4) : 255-71. PubMed Abstract Publisher Full...