近日,王福俤教授、周强研究员和闵军霞教授团队合作解析了细胞铁死亡关键转运蛋白xCT-4F2hc复合物结合铁死亡激活剂erastin的冷冻电镜结构,分辨率为3.4Å,功能验证了关键的药效结合位点,揭示了铁死亡激活剂erastin的作用机制。研究成果于2022年3月2...
The structure of erastin-bound xCT–4F2hc complexreveals molecular mechanisms underlying erastin-induced ferroptosisCell deathCryoelectron microscopydoi:10.1038/s41422-022-00642-wSpringer Nature SingaporeCell Research
Screening test for detection of active herbs facilitating gene expression of xCT (A) and 4F2hc (B).doi:10.1371/JOURNAL.PONE.0116275.G007H. KannoZ. KawakamiK. MizoguchiY. IkarashiY. KasePLOS ONE