本发明公开了xCT蛋白及其编码基因在神经变性病发生中的新用途. The present invention discloses a protein and its encoding gene xCT new use in neurodegenerative diseases carcinogenesis. 该xCT蛋白及其编码基因的新用途是首次发现了xCT蛋白及其编码基因在神经变性病中的发生机制,即发现了一种可以导致神经变性病的新...
Disclosed is a novel use of xCT protein and gene coded by same in generation of nerve degeneration diseases. It is discovered for the first time that xCT protein and gene coded by same relates to generating mechanism of nerve degeneration diseases. A novel gene causing nerve degeneration ...
GSH biosynthesis involves xCT coded by the SLC7A11 gene, a plasma membrane-bound sodium-independent antiporter that imports cystine and exports glutamate in a 1:1 ratio [48]. Intracellular cystine is reduced to cysteine and serves as a limiting precursor of GSH synthesis by γ-glutamylcysteine sy...
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联系人:Dr.Xu, Biovector NTCC Inc. 电话:400-800-2947 工作QQ:1843439339 (微信同号) 邮件:Biovector@163.com 手机:18901268599 地址:北京 已注册详细信息 咨询记录(共0条) 【Plasmid Name质粒名称】: lentiCRISPR v2-sgSLC7A11/xCT-2【Gene/Insert插入基因名称】: solute carrier family 7 member 11 (Homo...
5 mM0.34 mL1.68 mL3.35 mL Molarity Calculator Reconstitution Calculator Dilution Calculator 产品说明书 for XCT 790 分析证书/产品说明书 化学品安全技术说明书 参考文献 for XCT 790 参考文献是支持产品生物活性的出版物。 Lanvinet al(2007)Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-...
(1,2). The human xCT gene is located on chromosome 4q28.3 and is synthesized as a 12-pass transmembrane protein with both the N- and C-terminals located intracellularly (2, 3). xCT is a 501 amino acids (aa) protein with a theoretical molecular weight of 55.4 kDa (3, 4). xCT ...
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The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi-omics study .#SLC7A11 not only deeply influences RCC prognosis and TIM, but also promotes RCC progression by inhibiting ferroptosis and inducing metabolic reprogramming... - 《Cancer Medicine》 被引量: 0发表: 2021...
More interestingly, xCT plays a critical role in pheomelanogenesis as shown in subtle grey mice generated by knocking out of xCT gene, slc7a1121. We proposed that riluzole inhibits the release of glutamate through the glutamate/cystine transporter, xCT. In the absence of xCT, the glutamate ...