IKK2DN and MKK7DN overexpression in RAW cells specifically suppressed the NF-kappaB activation and JNK activation in response to RANKL, respectively, without affecting other signaling pathways. Either inhibition of NF-kappaB or JNK pathways dose-dependently inhibited osteoclast formation induced by RANKL...
JNK2 and p38α are closely related mitogen-activated protein kinases that regulate various cellular activities and are considered drug targets for inflammatory diseases. We have determined the X-ray crystal structure of the clinical phase II p38α inhibitor BIRB796 bound to its off-target JNK2. Th...
Date: Tuesday, October 8, 2024 at 4:07 AM To: CCP4BB@JISCMAIL.AC.UK <CCP4BB@JISCMAIL.AC.UK> Subject: Re: [ccp4bb] Review: Linearity and Resolution in X-Ray Crystallography and Electron Microscopy Dear Marin, In crystallography we do have the information gain measure (based on Kullb...
April 29th, 2021 at 4:32 pm Stjnky Says: I’m here because I spent my hard-earned savings on a Monster Ghost as a kid, and I learned this valuable life lesson: if I am ever considering buying something that comes with a “remote control,” always confirm that it’s not just a...
The irradiation or melatonin did not influence the JNK1 expression in Jurkat cells. The present results suggest that melatonin enhances radiation-induced apoptosis in Jurkat leukemia cells, while reducing radiation-induced apoptosis in normal mice splenocytes. These differential effects on radiation-...
Introduction Protocol Results Discussion Disclosures Acknowledgements Materials References English Automatically Generated Choat, B., Brodersen, C. R., McElrone, A. J.Synchrotron X-ray microtomography of xylem embolism in Sequoia sempervirens saplings during cycles of drought and recovery.New Phytologist.20...
2-Pyridineformamide N(4)-ring incorporated thiosemicarbazones inhibit MCF-7 cells by inhibiting JNK pathway Bioorg. Med. Chem. Lett., 29 (2019), pp. 1677-1681, 10.1016/j.bmcl.2019.04.031 View PDFView articleView in ScopusGoogle Scholar [11] W.A.A. Arafa, A.A. Ghoneim, A.K. Mo...
aindicating a significant contribution of JNK activation in age-related disruption of gut homeostasis. 表明JNK活化作用的一个重大摊缴在食道同态的与年龄有关的中断。[translate] ai went to play badminton with my aunt 我去打羽毛球与我的伯母[translate] ...
N-acetylcysteine attenuates ischemia-reperfusion-induced apoptosis and autophagy in mouse liver via regulation of the ROS/JNK/Bcl-2 pathway. PLoS ONE 2014, 9, e108855. [Google Scholar] [CrossRef] Yang, L.; Tan, P.; Zhou, W.; Zhu, X.; Cui, Y.; Zhu, L.; Feng, X.; Qi, H.; ...
International Journal of Molecular Sciences Article Effect of AICAR and 5-Fluorouracil on X-ray Repair, Cross-Complementing Group 1 Expression, and Consequent Cytotoxicity Regulation in Human HCT-116 Colorectal Cancer Cells Ko-Chao Lee 1, Chien-Tsong Lin 2,3, Shun-Fu Chang 4, Cheng-Nan Chen 5...