为了研究单个顺式元件以不同亲和力结合WUS并激活CLV3的机制,以及多个顺式元件之间在调节CLV3表达中的相互作用,研究人员开发了一个随机模型来模拟单细胞中WUS与CLV3 CRM的结合,以及RNA Pol II的募集和CLV3 mRNA的合成。结果显示,WUS单体与不同亲和力的单个顺式元件结合的停留时间限制,在很大程度上与它们单独激活CLV3...
论文共同第一作者、山东农业大学教授苏英华告诉《中国科学报》,前人研究发现,WUS基因能够编码分生组织中的关键调控因子,激活干细胞特征基因CLV3在干细胞中表达,并赋予它们干细胞的特征。2002年,有三篇关于WUS的重要论文问世,但其结论反而使得WUS的调节机制扑朔迷离。这三篇论文都从表型层面探讨了以WUS为核心的干细...
茎端分生组织是植物茎,叶和花等地上部分器官发生的来源.茎端分生组织的组织中心和其上方的干细胞构成的干细胞微环境是维持分生组织的基础.WUSCHEL(WUS)编码组织中心的关键调控因子,能够诱导干细胞特征基因CLAVATA3(CLV3)在组织中心上方的细胞中表达,并赋予它们干细胞的特征.尽管目前对WUS的功能有了一定的认识,但是对...
Our further work on the wus and clv3 mutants implicates that such two-step patterning is likely critical for the maintenance of AM progenitor cells and the specification of AM stem cell niche. These data provide a cytological frame for how a stem cell niche is established during AM formation....
解析:对拟南芥突变体的研究证明STM、WUS、LV1和LV3基因对维持正常茎顶端分生组织功能起上方主要包括作用。STM是胚胎形成茎顶端分生组织所必需的,维持茎顶端生长发育分生组织的发育与SL基因表达有关,在球形胚晚期的顶端圆柱形区域中所表达。WUS已经形成是形成和保有茎顶端分生组织所必需的,最初在球形原生质早期的顶细胞...
Overexpression of CLV3 causes constitutive repression of the WUSCHEL (WUS) gene (Brand et al., 2000), which encodes a putative homeodomain transcription factor that promotes stem cell format 在移居入寄主植物根以后, H。 glycines选择一pericycle创始含胞体 (Hussey & Grundler 1998年)。 CLV3 ...
WUSWUSCHELSeed plants have a remarkable capability to produce axillary meristems (AM) in the leaf axils, however, the dynamic establishment of a stem cell niche in AM is largely uncharacterized. We comprehensively examined the dynamic patterning of WUSCHEL (WUS) and CLAVATA3 (CLV3), the two ...
WUS and CLV3 expression in the eif3h mutant.Fujun, ZhouBijoyita, RoyJohn R., DunlapRamya, EngantiAlbrecht, G. von Arnim
Meng Ling,Feldman Lewis J.CLE genes may act in a variety of tissues/cells and involve other signaling cascades in addition to CLV3-WUS-like pathways. Plant signaling & behavior . 2011Meng L, Feldman LJ. CLE genes may act in a variety of tissues/cells and involve other signaling cascades ...
Nikolaev SV, Penenko AV, Lavreha VV, Mjolsnes ED, Kolchanov NA (2007) A model study of the role of proteins CLV1, CLV2, CLV3, and WUS in regulation of the structure of the shoot apical meristem. Russ J Dev Biol 38: 383-388....