Hilton DJ, Watowich SS, Katz L, Lodish HF 1996 Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor. J Biol Chem 271:4699 - 4708Hilton DJ,Watowich SS,Katz L,et al.Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor. Journal of Biological Chemistry ....
The "WSXWS" motif, conserved in the cytokine receptor family, was shown to not be required for dimerization. Diagonal two-dimensional gel analysis of the EpoR expressed in DA-3 transfectants showed that a substantial portion of the receptor forms dimers or oligomers with disulfide bonds. Western...
WSXWS motif is a conserved amino acid sequence that is present in type I cytokine receptors. This motif that can be found both in the ligand binding chains and signal transducer molecule of the receptors with different amino acids at the position "X" plays a role in the receptor folding, ...
Members of the cytokine receptor family have a consensus WSXWS sequence (WS motif) in the extracellular domain. With the interleukin-2, erythropoietin, and prolactin receptors, alteration of the WS sequence disrupts ligand binding and receptor signaling. The structural basis for these effects is ...
Furthermore, a mutation within the WS motif of IL-21R was recently shown to cause a novel kind of primary immunodeficiency syndrome (PID). Here, we report the structure of IL-21R alone, which shows that the sugar bridge forms independently of whether IL-21R binds IL-21 or not, and ...
The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor . Structure 2012 ; 20(2): 270 – 82 . ,Dagil R, Knudsen MJ, Olsen JG, O'Shea C, Franzmann M, Goffin V, et al. The WSXWS motif in cytokine...
To evaluate the effect of this modification, aC-mannosyltryptophan containing glycopeptide of human erythropoietin receptor (EPOR), which includes WSXWS motif conserved in cytokine receptor superfamily, was synthesized by microwave assisted solid-phase synthesis using per-O-benzyl protected amino acids and...
Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R. Hamming, Ole J.,Kang, Lishan,Svensson, Anders,Karlsen, Jesper L.,Rahbek-Nielsen, Henrik,Paludan, Sren R.,Hjorth, Siv A.,Bondensgaard,...
Heterozygous mutation in the WSXWS equivalent motif of the growth hormone receptor in a child with poor response to growth hormone therapy. Growth Horm IGF Res. 1998;8:211-6.M.T.Tauber,V. Porra,F,Dostot,et al.Heterozygous mutation in the WSXWS equivalent motif of the growth hormone ...