药品名称 WSD0628 药品类别 创新药; 化药; 小分子; potential first-in-class; DNA损伤反应; 蛋白激酶; 合成致死; p53信号通路 靶点 ataxia telangiectasia mutated (ATM) 作用机制 ATM抑制剂; 放射增敏剂 药品简介 WSD0628 is a robust radiosensitizer and has moderate brain penetration that is not...
WSD0628 is highly selective over other kinases. In-vitro MDCKII transfected cells and Caco-2 assays have shown that WSD0628 is highly permeable and not a substrate of P-gp or BCRP, two main efflux transporters expressed on human BBB. Preclinical CNS PK studies in rat and mouse confirmed ...