DIABETIC FOOT ULCERSERRORMULTIDISCIPLINARYMANAGEMENTObjectivesExact wound diagnosis is essential for successful wound management and a holistic care of the patient suffering from a wound. Wound management has been traditionally seen as a nursing area, but this can lead to considerable delays in wound ...
In 1997, PDGF, or becaplermin, became the first and only US Food and Drug Administration (FDA) approved growth factor to be used in wound healing under the trade name Regranex, specifically for diabetic foot ulcers. PGDF is chemotactic for neutrophils and macrophages, and hence plays an ...
Chronic wounds are thought to be a consequences of either endogenous factors, such as impaired angiogenesis as seen in diabetic patients, or exogenous factors, such as excessive presence of pathogens [10]. In both cases, the wounds display distinct molecular signatures that are either a consequence...
The pH of wound fluid in diabetic foot ulcers—the way forward in detecting clinical infection? Curr. Diabetes Rev. 2014, 10, 177–181. [CrossRef] [PubMed] 174. Cui, T.; Yu, J.; Wang, C.F.; Chen, S.; Li, Q.; Guo, K.; Qing, R.; Wang, G.; Ren, J. Micro-Gel ...
For example, the treatment of chronic wounds (in case of diabetic foot, venous ulcers, and pressure ulcers) habitually involves long-term therapy. Given current problems posed by these infections, the antimicrobial potential of unconventional, non-antibiotic treatments has a renewed interest. In ...
NETs are increased in diabetic foot ulcer (DFU) patients compared to healthy patients [37]. NETs such as citrullinated histone 3 were suggested as potential negative markers for wound healing [37]. In summary, the persistent presence of neutrophils at the wound site delays the healing process ...