Furthermore, other carrageenans micro-drug delivery systems (e.g., microspheres, pellets) have also been developed [171]. The similarity of the sulfated backbone structure of carrageenan to that of mammalian GAGs makes carrageenan-based wound dressings effective in promoting wound healing [170]. ...
All Special Issues3D Printing of Pharmaceuticals and Drug Delivery DevicesABC Transporter-Mediated Drug DispositionAdvanced Formulation Approaches for Targeted Drug DeliveryAdvanced Ocular Drug DeliveryAdvanced Pharmaceutical Science and TechnologyAdvanced Polymeric Delivery Systems for Cancer TherapyAdvanced Transdermal...
Wound healing (WH) is a complex multistep process in which a failure could lead to a chronic wound (CW). CW is a major health problem and includes leg venous ulcers, diabetic foot ulcers, and pressure ulcers. CW is difficult to treat and affects vulnerab
Next, a scalpel blade was used to remove the entirety of an excised lesion on the rear epidermis of rats near the dorsal collar aspect that was 2 cm wide (circumferential area: 4 cm2). After the operation, the rats were placed individually in metabolic cages. 4.8.3. Experimental Design ...
Thus, the modification, correction, or prevention of diabetes impaired wound healing has far-reaching consequences, both on patient outcomes and on healthcare expenditures. Normal wound repair follows an orderly and well-defined sequence of events that requires the interaction of many cell types, ...
It remains always true that insufficient nutrient and oxygen delivery to the tissue will result in cell death and tissue breakdown, as life occurs far from thermodynamic equilibrium. Since the vascular system supplies all the required substrates (lower entropy) and removes all the wastes (higher ...