Further, the blockade of Ca2+ release or calcineurin (CaN) or nuclear factor of activated T-cells (NFAT) functions resulted in an inhibition of cartilage differentiation. Together, our results demonstrate that non canonical WNT5A-Ca2+-CaN-NFAT signalling plays a key role during embryonic digit ...
此外,网膜蛋白抑制WNT5A/Ca2+信号通路,促进线粒体生物发生功能,改善心肌缺血损伤。然而,在体外,WNT5A敲低抑制了线粒体生物发生的损伤,并部分抵消了网膜蛋白的心脏保护作用。因此,本研究表明,Rd通过TBK1-AMPK途径促进脂肪细胞分泌网膜蛋白,通过WNT5A/Ca2+信号通路改善线粒体生物发生功能,改善心肌缺血损伤,为HF的治疗...
(1.湖北省十堰市太和医院推拿科,湖北十堰442000;2.湖北省十堰市太和医院中西医结合科,湖北十堰442000 ) [摘要] 目的探究体外冲击波治疗通过激活W n t 5a /C a 2+信号改善大鼠股骨牵张成骨的机制㊂方法60只8 周龄S p r a g u eD a w l e y 雄性大鼠分为对照组㊁股骨牵张模型组和体外冲击波...
The Wnt5a binds to receptors and activates Wnt5a/Ca2+ signaling in response to silica particle stimulation, with increased expression phos-CaMKII and Nfat1. The activated Wnt5a/Ca2+ signaling regulated the silica-induced ER-stress to increase calcium (Ca2+) release and activate Aft6/Bip/Chop ...
目前已知wnt信号通路有三种,即经典wnt/β-catenin通路以及两个非经典通路(wnt-平面细胞极性通路(wnt-planar cell polarity pathway,wnt-pcppathway)和wnt-钙离子通路(wnt-calcium pathway,wnt-ca2+pathway)。触发途径的特异性取决于wnt和frizzled(fzd)共受体的组合、细胞类型和细胞环境。其中经典wnt/β-catenin通路级联...
Authors - Weilin Fang View Article human WB,IF Noncoding RNA Res LncRNA NEAT1-206 regulates autophagy of human umbilical cord mesenchymal stem cells through the WNT5A/Ca2+ signaling pathway under senescence stress Authors - Weili Wang View ArticleProteintech...
receptors at the cell surface9,10and upregulates synaptic N-methyl-D-aspartate receptor (NMDAR) currents in the hippocampus, stimulating the induction of long-term potentiation (LTP)11. Besides, several evidences show that in cultured hippocampal neurons Wnt5a-induced activation of Wnt/Ca2+...
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张曼等大黄灵仙方对LPS 诱导的肝内胆管组织损伤大鼠炎症反应及Wnt5a -Ca 2+-PKC 信号转导通路的影响第1期大黄灵仙方对LPS 诱导的肝内胆管组织损伤大鼠炎症反应及Wnt5a -Ca 2+-PKC 信号转导通路的影响① 张曼②戴建业③俞渊④唐乾利⑤ 陈金梅④（湖南中医药大学研究生院，长沙410208）中图分类号 R575.6...
Wnt 5a协同Wntll共同作用参与Wnt/Ca2+通路,从而促使细胞胞浆内 Ca2+浓度升高引起钙调调节蛋白依赖激酶及T细胞核因子的激活[28]。诸多研究表明,异 常的Writ信号转导可能一些肿瘤、炎症性疾病的发病过程中的重要机制。 Wnt5a通过不同的受体激活经典或非经典的Wnt信号通路。Wnt5a通过非经典的信号 通路可抑制Wnt/13....