体内成像显示病毒有效感染大鼠右半球,Western blotting 和定量 PCR 分析证实 Frizzled - 2 成功敲低。 (六)Frizzled - 2 敲低对脑缺血再灌注后大鼠脑组织和 PC12 细胞中 Wnt/Ca2?信号通路的影响 构建基于 Frizzled - 2 敲低的 I/R 模型,Western blotting 和免疫荧光检测发现,I/R 组 Wnt5a、Frizzled - 2...
主要研究内容包括: 1. 从分子水平阐述非经典Wnt信号通过PKC和NFAT对经典Wnt信号(Wnt/β-catenin)产生抑制的分子机制; 2. 利用干细胞分化模型初步探索NFAT分子在非经典Wnt信号的调节下参与心肌分化的作用方式。 此项工作旨在揭示非经典Wnt信号的胞内信号转导机制,及其对经典Wnt信号发挥抑制的分子调控机制,并阐述这种调...
炎症反应、神经细胞内信号传导及代谢反应相关,借助改良Hulth法诱导的大鼠膝骨关节炎疼痛模型观察盘龙七片对膝骨关节炎疼痛的作用特点,发现盘龙七片不仅可以用于缓解膝骨关节炎急性发作期疼痛,而且对疾病后期慢性持续性疼痛仍然具有良好的镇痛...
Wnt11皮肤黑素瘤是一种高恶性,发展快,易转移,预后差的恶性肿瘤,然而,目前还缺少能确定黑素瘤是否具有高侵袭性的特异性标志.Wnt信号通路是近年来备受关注的一条调控胚胎发育和肿瘤形成的信号转导途径,目前认为,Wnt信号通路包括经典Wnt/β-catenin途径和非经的Wnt/Ca2+途径及Wnt/JNK途径,已有的文献资料及我们的前期...
Endothelial Rspo3 Controls Vascular Stability and Pruning through Non-Canonical Wnt/Ca (2+)/Nfat Signaling. Dev Cell. 36, 79-93 (2016).Scholz, B., Korn, C., Wojtarowicz, J., Mogler, C., Augustin, I., Boutros, M., Niehrs, C. and Augustin, H. G. (2016). Endothelial ...
目的:体外探讨Wnt1 1/Ca2信号通路在炎症条件下对BM-MSCs成骨分化的调节作用.方法:BM-MSCs在多浓度(100ng/ml,1000ng/ml,10000ng/ml,100000ng/ml)的SPA刺激下成骨分化,分别予以诱导0,7,14,21天;另外分别建立过表达wnt11和siRNA干扰wnt11表达慢病毒载体系统,转染BM-MSCs,... 查看全部>>关键...
Moreover, the Ca2+ is also an important messenger to bridge the communication gap between mitochondrial organelles and ER (Giamogante et al. 2020). However, mechanisms underpinning the regulation of intracellular Ca2+ in ferroptosis have yet been established. Wnt signaling is an evolutionarily ...
plcδ3ais a target gene of Wnt signaling. Lack of Connexin43 (Cx43), especially its channel function, decreases motile cilia and intercellular Ca2+wave (ICW) propagation. Genetic ablation ofcx43in zebrafish and mice diminished motile cilia. Finally,Cx43is also expressed in ECs of the human ...
此外,网膜蛋白释放的增加可以通过抑制WNT5A/Ca2+信号通路来改善线粒体的生物发生功能,从而改善心肌缺血损伤。因此,Rd可以调节脂肪细胞和心肌细胞之间的串扰,以改善心肌缺血损伤(如图8所示),这不仅提出了新的机制见解,而且将Rd确定为心衰治疗的潜在候选药物。
Activation of Intracellular Calcium by Multiple Wnt Ligands and Translocation of β-Catenin into the Nucleus A CONVERGENT MODEL OF Wnt/Ca2+ AND Wnt/β-CATENIN PATHWAYS Activation of intracellular Calcium by multiple Wnt ligands and translocation ofβ-catenin into the nucleus:a convergent model of ...