Vital elementsof the Wnt-Frizzled signaling pathway in the nervous system. Curr NeurovascRes. 2005 Oct;2(4):331-40. PubMed ID: 161811244. Urano T. Wnt-beta-catenin signaling inbone metabolism. Clin Calcium. 2006 Jan;16(1):54-60. PubMed ID: 1639...
11. Katoh M. WNT/PCP signaling pathway andhuman cancer. Oncol Rep. 2005 Dec;14(6):1583-8. PubMed ID: 16273260 12. Timm A, Grosschedl R. Wnt signaling inlymphopoiesis. Curr Top Microbiol Immunol. 2005;290:225-52. PubMed ID: 16480045 13. Janssens N, Janicot M, Perera T. TheWnt-d...
经典Wnt信号通路,即Wnt/β-cantenin信号通路 Wnt/PCP通路(planner cell polarity pathway) Wnt/Ca2+通路,由Wnt5a和Wnt11激活 这3条信号通路主要成分包括:分泌蛋白Wnt家族、跨膜受体Frizzled家族、CK1、Deshevelled、GSK3、APC、Axin、β-Catenin、以及转录因子TCF/LEF家族。 不过我们一般提到Wnt信号通路,主要指的还是...
3. MacDonald BT, et al. Wnt/beta-cateninsignaling: components, mechanisms, and diseases. Dev Cell. 2009Jul;17(1):9-26.4. T Zhan, etal. Wnt signaling in cancer. Oncogene. 2017 Mar;36(11):1461-1473.5. Theka I, et al. Wnt/β-catenin signaling pathway safeguards epigenetic stability ...
11. Katoh M. WNT/PCP signaling pathway andhuman cancer. Oncol Rep. 2005 Dec;14(6):1583-8. PubMed ID: 16273260 12. Timm A, Grosschedl R. Wnt signaling inlymphopoiesis. Curr Top Microbiol Immunol. 2005;290:225-52. PubMed ID: 16480045 ...
值得注意的是这里的APC的全称是APC Regulator Of WNT Signaling Pathway ,其中字母APC是Adenomatous Polyposis Coli protein( 腺瘤性结肠息肉病蛋白)的简写 。这个蛋白是通过腺瘤性结肠息肉这种遗传病中被发现的,是一种抑癌基因。注意,这个APC不同于“细胞周期通路”那一章中的后期促进复合物APC/C。
11. Katoh M. WNT/PCP signaling pathway andhuman cancer. Oncol Rep. 2005 Dec;14(6):1583-8. PubMed ID: 16273260 12. Timm A, Grosschedl R. Wnt signaling inlymphopoiesis. Curr Top Microbiol Immunol. 2005;290:225-52. PubMed ID: 16480045 ...
11. Varelas X, et al. The Hippo pathway regulatesWnt/beta-catenin signaling. Dev Cell. 2010 Apr 20;18(4):579-91. 12. Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocyticleukemia cells.Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):...
10. 尹定子, 宋海云. Wnt信号通路:调控机理和生物学意义[J]. 中国细胞生物学学报, 2011, 033(002):103-111. 11. https://www.sinobiological.com/pathways/canonical-wnt-pathway 12. Pan, D. (2010). The hippo signaling...
wnt信号通路(TheWnt signaling pathways)是复杂的生物信号转导结构网的一条。其主要分为经典wnt信号途径和非经典wnt信号途径。Wnt信号通路参与众多重要的生理病理过程,Wnt通路调节造血干细胞及造血微环境,Wnt通路参与控制神经前体细胞的增殖分化,在正常干/祖细胞池的保持方面有重要作用,且Wnt信号通路与肿瘤的发生息息相关...