and blocking Wnt ligand secretion by inhibiting porcupine activity may suppress full activation of the Wnt signaling pathway140. The small molecule Wnt-C59 is a strong and specific porcupine inhibitor and has been shown to inhibit the stemness properties in various NPC cell lines by arresting tumor...
Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice Article Open access 25 January 2021 Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle Article 14 September 2020 Single-cell transcripto...
However, increased Wnt signaling is not sufficient to induce a full osteogenic response, which is consistent with Wnt pathway activation in developing valves and postnatal valves that do not normally calcify. Similarly, osteogenic media induces multiple markers of bone differentiation and calcification in...
The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response. Accumulated investigations highlight the therapeutic potential
Fig. 1: Inhibition of the Wnt/beta-catenin signaling enhances GC cells’ sensitivity to ferroptosis. Full size image TCF4 acts as a repressor of ferroptosis in GC cells Fig. 2: TCF4 acts as a repressor of ferroptosis in GC cells.
Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm 喜欢 0 阅读量: 31 作者:CM Bouldin,AJ Manning,YH Peng,GH Farr,KL Hung,A Dong,D Kimelman 摘要: Anterior to posterior growth of the vertebrate body is fueled by a posteriorly located population of bi...
Full size image STAMBPL1 regulates the WNT/PI3K/ NF-kb signaling pathway in HCC In order to explore potential signaling pathway and biological functions correlated with the expression of STAMBPL1 in HCC, HCCLM3 cell lines transfected with shRNA were examined by the next generation sequencing (NGS...
Loss of ESRP2 Activates TAK1-MAPK Signaling through the Fetal RNA-Splicing Program to Promote Hepatocellular Carcinoma Progression 发表期刊:Advanced Science IF: 15.1 发表单位:中山大学附属第六医院 吉凯助力:ESRP2干扰慢病毒 文章摘要:肿瘤通常表现出类似胎儿的特征,并且已经鉴定出许多癌胚蛋白。然而,肝细胞癌...
Gsk-3β expression increased significantly while the expressions of β-catenin and Wnt1 were significantly lowered in the hippocampus of the offspring rats in PS group (P< 0.01).ConclusionPS causes changes in Wnt/β-catenin signaling pathway in the hippocampus to contribute to the occurrence of ...
Full size image To study a possible connection between cardiac hypertrophy and Wnt/β-catenin signaling, we carried out a comprehensive analysis of the mRNA expression of all Wnt ligands in the heart after Ang II infusion. Quantitative, real-time RT-PCR (qRT-PCR) revealed that, of the 19 ...