BONE fracturesBackground: The role of the Wnt pathway in bone and its targets in skeletal disease has garnered interest, but the field lacks a systematic analysis of research. This paper presents a bibliometric study of publications related to the Wnt signaling pathway ...
Gene researches in humans and mice have established Wnt signaling as a key mechanism for stimulating osteoblast differentiation and activity.This paper reviews the related mechanisms of Wnt signaling pathway and bone formation and the treatment of osteoporosis. [Key words] Bone cell;Wnt;Osteoporosis;...
Role of the Wnt signaling pathway in bone and tooth Signaling by the Wnt plays a central role in many processes during embryonic development and adult homeostasis. At least 19 types of Wnts, several families of secreted antagonists and multiple receptors have been identified. Two distinct... M...
Our results support the addition of bone protective agents when treating patients with PORCN inhibitors. Mitigation of bone toxicity can extend the therapeutic utility of Wnt pathway inhibitors.Similar content being viewed by others Targeting strategies for bone diseases: signaling pathways and clinical ...
Wnt signaling is a major regulator during development. Genetic mutations affecting main regulators of this pathway have also emphasized the relevance of Wnt signaling in bone homeostasis after birth and diseases involving bone loss and fragility, such as
the ratio of osteoprotegerin/receptor activating factor ligand, promotes the osteoclasts differentiation and immaturation. The researches addressing the components and effect of Wnt signal pathway are important for the special treatment of bone diseases and the prevention of osteoporosis or other bone ...
Given that the majority of disease states are characterized by an inadequate renewal of osteoblasts, and the canonical wingless (Wnt) pathway is critical for their differentiation from progenitors, this represents an intriguing target for bone therapy. This mini-review focuses on the different options...
Exosomes Derived from Adipose Stem Cells Enhance Bone Fracture Healing via the Activation of the Wnt3a/β-Catenin Signaling Pathway in Rats with Type 2 Dia... All these results show that ASCs-exos enhance the osteogenic potential of BMSCs by activating the Wnt/尾-catenin signaling pathway, and...
The Wnt signaling pathway is a complex molecular pathway involved in various types of cancers, including breast, colon, and skin cancer. It consists of Wnt ligands and receptors and plays a significant role in regulating cell self-renewal, apoptosis, and metastasis. Targeting this pathway can inhi...
M. β-catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells. Stem Cells 27, 1109–1119 (2009). Article CAS PubMed PubMed Central Google Scholar Malhotra, S. & Kincade, P. W. Wnt-related molecules and signaling pathway ...