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Only normal control patients and patients with confirmed IPF were used from the dataset. Statistical analysis Data represent means ± SEM, from n independent experiments. Statistical significance of differences was evaluated by Student’s t-test or one-way ANOVA followed by a Newman-Keuls ...
WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the CCN family able to mediate cell growth, transformation and survival in a tissue-specific manner. Here, we report that WISP1 expression was highly increased in pread
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Figure 4 Results Expression of CCN6 in immortalized human mammary epithelial cells A CCN6-specific receptor has not yet been cloned; blockade of the receptor is therefore not yet feasible as a means of inhib- iting CCN6 function. Thus, to investigate the role of CCN6 in the mammary ...
The fibrotic area was quantified with Image-Pro Plus 6.0 (IPP6.0). As previously described,16 the grade of LF fibrosis was classified on the basis of the percentage of collagen in the entire area of the sample, as follows: Grade 0, less than 20%; Grade 1, between 20 and 25%; Grade...
1C). Moreover, only the potentials of cell migration and invasion of HCC827, H460, and H1299 cells were significantly enhanced by fibronectin, while an inhibitory function was observed in A549 and H9175 cells (Fig. 1D &E, and S Fig. 1). Next, the role of fibronectin on tumor growth...
In (C)–(E), data are represented as means ± SEM; ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 using an ANOVA followed by a Bonferroni post hoc test. See also Figures S4 and S5. To confirm that FAPs are the principal cell type in which aging affects WISP1 secretion,...