Wilson's disease (WD) is a rare genetic disorder inherited as an autosomal recessive trait. The signs and symptoms of this disease are related to dysfunctional ATP7B protein which leads to copper accumulation and cellular damage. The organs that are most commonly affected by WD are the liver ...
Not Wilson's disease: a review of misdiagnosed cases During the period 1957鈥 1987, 189 patients with neurological signs and symptoms were referred to the Wilson's disease clinic at Addenbrooke's Hospital, Cam... JM Walshe,M Yealland - QJM 被引量: 29发表: 1995年 ...
Wilson disease can often be diagnosed through clinical assessment and noninvasive tests, but aliver biopsymay be needed if the clinical signs and noninvasive tests are indeterminate or if there is suspicion for alternative or additional liver diseases.53The Working Party at the 8th International Meeti...
Wilson's Disease]]>Patients with neurological symptoms and signs of Wilson's disease have been frequently noted to have a worsening of their condition after beginning chelation therapy with D-penicillamine. Presymptomatic patients, however, are not expected to develop ...
Wilson disease is present at birth, but symptoms usually start between ages 5 and 35. It first attacks the liver, the central nervous system or both. The most characteristic sign is a rusty brown ring around the cornea of the eye. A physical exam and laboratory tests can diagnose it. Trea...
Wilson's disease (WD) is a genetic disorder of copper metabolism with pathological copper accumulation in many organs, resulting in clinical symptoms, mostly hepatic and neuropsychiatric. As copper accumulates in the brain during WD, and almost 50% of WD patients at diagnosis ...
Wilson's disease is clinically characterised by signs of cirrhosis, extra-pyramidal syndrome with hypertonia, shivering, and hypercinesia. It is of a family nature and is characterised by the corneal rign of Kayser-Fleischer; the disease is also known as hepato-lenticular degeneration. Moreover,...
Wilzin is usually not recommended for initial therapy of patients with signs and symptoms of Wilson’s disease because of its slow onset of action. Yfirleitt er ekki mælt með notkun Wilzin sem upphafsmeðferð hjá sjúklingum með merki og einkenni Wilsons sjúkdóms þar...
The hallmarks of the disease are the presence of liver disease, neurologic symptoms, and Kayser–Fleischer corneal rings. The leading neurologic symptoms in WD are dysathria, dyspraxia, ataxia, and Parkinsonian-like extrapyramidal signs. Defective in a Cu-dependent P-type ATPase (ATP7B) function ...
Because of various manifestations of Wilson's disease, physicians should have high index suspicion when patients manifest any type of liver disease, neurologic and psychiatric signs and symptoms.年份: 2010 收藏 引用 批量引用 报错 分享 全部来源 求助全文 comprped.com ...