Additional mechanisms that may lead to an altered balance of pyruvate metabolism in cardiac hypertrophy are discussed, with commentaries on possible changes in pyruvate transport, NADH shuttles, lactate dehydrogenase, and amino acid metabolism. 展开 关键词: Cardiac hypertrophy Glycolysis Glucose oxidation ...
People with genetic lactate dehydrogenase deficiency experience fatigue when attempting any exercise. Explain the etiology of this disease. What causes the lack of energy? What is the difference between nephrotic syndrome and nephrosclerosis? Why does edema develop i...
After centrifugation (2,500×g, 5 min, 22°C), undiluted plasma was removed and stored at −80°C for further analysis. Metabolic and organ injury/function parameters In the first experiment (28 day follow-up), urea nitrogen (urea), glucose, lactate dehydrogenase (LDH) and alanine ...
degeneration of primarily unmyelinated sensory axons in transgenic mice. As compensation for the loss of oxidative metabolism, the mice upregulated glycolytic pathways and had increased lactate production. To demonstrate that lactate production was partially protective, the investigators blocked production of ...