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Chemical modification is introduced either during protein digestion (O18-labelling) or at peptide level using isobaric peptide tags for relative and absolute quantification (iTRAQ), tandem mass tags (TMT) or dimethyl labelling introduced during sample preparation [233–238]. In addition, MS ...
To do so, a dimensionless time variable χ∈ R is defined so that t = χ T 2 , therefore χ∈ [0, 2nT]. The observations and the sought constant rate response can be written as h(χ, T) and g(χ, T), respectively, and, adopting the definition of q introduced for method 2, ...