Only one strand of DNA is used during transcription. Why? Why are the two strands of DNA antiparallel? Why can't we build functioning DNA/RNA in a lab? Why is telomerase important for DNA replication? How the structure of DNA contributes to a cell's ability to replicate it?
Why is it important that DNA replication not be 100% accurate? (a) Describe the levels of DNA packaging. (b) Why is this important to the cell? Why is telomerase important for DNA replication? Why is the deoxyribose so important in DNA and why is the phosphate at the 5' end crucial ...
but when we analyze these cells chemically, we find something very interesting—a chemical in them, an enzyme called “telomerase.”As bits of the telomere break off from the end of the chromosome, this chemical—this “telomerase”—can rebuild it…can help reassemble the protective DNA, the...
Additionally, measuring telomere length is useful for identifying those at increased risk of genetic defects in the telomerase gene complex [10]. There is growing evidence that unsuspected germline mutations not classically associated with inherited forms of marrow failure forms could underlie AA ...
Replicative Senescence and Cell Immortality: The Role of Telomeres and Telomerase Telomere shortening is correlated with cell senescence in vitro and cell aging in vivo. The telomere hypothesis suggests that telomere length serves as a m... CP Chiu,CB Harley - 《Proc Soc Exp Biol Med》 被引量...
and non-telomerase mechanisms for increasing the length of telomeres, we might find that one of these factors is more easily manipulated to slow aging or prevent cancer. Also there are additional factors that affect aging and cancer, which might prove in the end to be more important than telom...
Telomere shortening in mTR−/− embryos is associated with failure to close the neural tube Mice genetically deficient for the telomerase RNA (mTR) can be propagated for only a limited number of generations. In particular, mTR−/− mice of a m... E Herrera,E Samper,MA Blasco - 《...
The ssDNA-binding capacity of the Whirlies could be an important regulator of gene expression in organelles. Since StWhy1 has been shown to act as a transcriptional activator for the PR-10a nuclear gene in tubers following elicitation, it is plausible that AtWhy2 could take part in the regu...
(called Telomerase). This has a major effect on slowing the progression of aging. Another major benefit is that telomere lengthening decreases the risk of a wide variety of chronic diseases. It is believed that increases in the telomere length may help to prevent chronic health conditions and ...
one we can't get with the usual approach of trying to extend the lifespan of experimental animals, which are normally short-lived. But it's important to note that this work is limited in its own way, as it only looks at blood cells, when many important changes associated with aging und...