The efficient design of association mapping studies relies on a knowledge of the rate of decay of linkage disequilibrium with distance. This rate depends on the population recombination rate, C. An estimate of C for humans is usually obtained from a comparison of physical and genetic ma...
A genetic susceptibility to inflammatory bowel disease (IBD) is suggested by the familial incidence of 15-20%, disease concordance within monozygotic twins (especially for Crohn’s disease), and a remarkable concordance of disease characteristics within individual families. However, the pattern of inher...
Even in this case, it is important to design strategies that increase the power of detection.Key Words: Multifactorial disease,聽genome screen,聽candidate gene,聽linkage,聽associationF. Clerget-DarpouxINSERM U.535.80 rue du Général LeclercH. Selinger-Leneman...
malvis.hi.is 相似文献 参考文献Corporate Governance in Japan: Institutional Change and Organizational Diversity Debates regarding corporate governance have become increasingly important in Japan as the post-war model of bank-based, stakeholder-oriented corporate gove... ...
(GWASs) were supposed to provide a novel understanding of T2DM causation. However, the common variants found associated with T2DM provided little biological indication about their implication in T2DM pathogenesis; some were located in gene regions, but functional variants in linkage disequilibrium with ...
Linkage disequilibrium (LD). The nonrandom association between alleles at two or more loci, being indicative of a lack of recombination. Recombination reduces LD. Clonal interference The process by which beneficial mutations compete, and hence interfere, with each other as they proceed toward fixation...
Alternatively, the B allele may be in linkage disequilibrium with another, unidentified gene involved in calcium metabolism. In either case, this apparent association suggests that genetic factors related to calcium metabolism may be important in an individual patient's susceptibility to develop valvar ...
Among the various mechanisms involved in biological heritability (cytoplas- mic heritability, sex linkage disequilibrium, epigenetic transmission, niche con- struction, and so on), replication of DNA is the most important and central one because it allows the faithful conservation of genetic information...
Genetic LinkageLongitudinal studies in Sudan show ethnic differences in incidence and clinical phenotypes associated with Leishmania donovani. Immunologically, bias in type 1 vs type 2 cytokine responses is important. To determine whether polymorphisms at IL4/IL9 or IFNGR1 contribute to susceptibility, ...
Markets are in a state of constant disequilibrium and are examined in the context of cycles, trends, and structural breaks as illustrated in several real-world economic series that move both the economy and financial markets. The story of the Transcontinental Railroad is particularly important....