What is the purpose of adding tracking dye to the DNA samples? A) What do DNA damage checkpoints do? B) Why is it useful to have this type of checkpoint in G1? C) Why is it useful to have such a checkpoint in G2? Why is it important to include replication when conducti...
Explain how you can prevent cancer by preventing cell growth (Using the cell cycle checkpoints and G1/ S cyclin/ CDK) and trigger cell death. Why is it difficult to spare stem cells during cancer therapy? Explain how ionizing and non-ionizing radiation cause damage. Why might gamma irrad...
Efforts have been made to identify drugs that would block the G2 cell-cycle checkpoint (e.g. inhibitors of Chk1 or Wee1) [37]. The therapeutic rationale for these inhibitors is that in a p53 non-functional tumour cell, radiosensitisation or chemosensitisation would occur as both the G1 ...
Cholesterol homeostasis is crucial for mammalian cells, and it is therefore tightly regulated by complex signalling networks that control its synthesis, uptake, conversion, trafficking, and efflux (Fig.1) [9]. Cholesterol is an essential lipid, and it has multiple functions that are central for no...
Question: Why do cells experience adecreasein entropy while the universe isincreasingin entropy? Laws of Thermodynamics: Excluding the zeroth law, there are three fundamental laws of thermodynamics. The first law deals with the eternality of energy, that energy cannot be created...
Chemical modifications have also enabled the conjugation of large biomolecules onto exosomes, such as the design of an exosome-based immune checkpoint blocker that interferes with the CD47-SIRPα checkpoint on tumor cells, enhancing immune cell-mediated tumor cell engulfment, as Koh et. al. showed ...