Notably, vector readministration to further improve the FVIII levels is not feasible at this time. Thus, the need of a one-and-done AAV strategy to achieve sustain FVIII levels of expression is sine qua non to impact favorably the disease phenotype....
How this occurs, and how we can drive the process more reliably in the hyaline direction is currently unclear. A number of important questions remain when considering therapeutic strategies for cartilage regeneration: should cells be delivered, or can their secretome be used as an alternative [9]...
What: AD is uniquely human, but molecular mechanisms can be measured in Tg mice. • Who: A universal biological variable of AD, APOE is critical for preclinical models. • How: There are several strategies for developing APOE-Tg mice. • When/Where: Developmental and region-specific mode...
It has been suggested that diffusion may be important for the CSF-ISF exchange, but that advection drives flow along perivascular pathways [1], however, this is still an area of active research. A recent study of this process used modelling combined with directly measured tracer movement ...
In this review, the terms extracellular vesicles and exosomes are used interchangeably. In theory, one can differentiate between EVs, an umbrella term, and exosomes, a subtype of EVs. However, in practice, it is not easy to isolate a pure particular subtype without the presence of other ...
Introduction Patients affected by chronic kidney disease (CKD) or end-stage renal disease (ESRD) have a shorter life expectancy than those with normal renal function, primarily due to the dramatic increase in cardiovascular mortality [1]. Chronic hemodialysis treatment is associated with a 10 to ...