This has made some thoughtful persons doubt the assertions of public and private health agencies that reduction of tuberculosis has been largely due to, or at least has been very materially increased by, the campaigns of education and enforcement of early diagnosis, notification, early treatment, ...
Considering Mycobacterium tuberculosis, why did the rates of infection by the tuberculosis bacterium increase dramatically in the 1980's? Your mutant strain of bacteria does not form a biofilm. It appears to perform chemotaxis correctly, as well as ...
tuberculosisHIVRifabutinantiretroviral therapytreatment outcomespharmacokinetic interactionstoxicityswitchdrug‐resistant‐TBcost effectivenessIntroductionRifabutin, a rifamycin of equivalent potency to rifampicin, has several advantages in its pharmacokinetic and toxicity profile, particularly in HIV co‐infected patients...
Tuberculosis is a deadly and contagious disease that affects the lungs. It is caused by bacteria and can be transmitted from person to person via droplets in the atmosphere when a sick person coughs or sneezes. The most common symptoms of tuberculosis are fever, night sweats, co...
For example, new and serious antibiotic-resistant strains of tuberculosis have recently appeared. This evolution may have been encouraged by what some authorities consider our overuse of antibiotics, giving microorganisms a greater chance to evolve resistance by exposing them to a constant barrage of ...
& Gori, A. T-cell exhaustion in Mycobacterium tuberculosis and nontuberculous mycobacteria infection: pathophysiology and therapeutic perspectives. Microorganisms 9, 2460 (2021). Article CAS PubMed PubMed Central Google Scholar Moldawer, L. L. & Sattler, F. R. Human immunodeficiency virus-...
This podcast series will take you on a journey to explore what is possible and help you believe that humanity can save itself and our planet. Listen now Summary AI has the power to accelerate solutions to tackle global challenges and structural inequalities. But its potential to...
In recent decades, the number of antibiotic-resistant infections has increased dramatically and Mycobacterium tuberculosis, a bacterium that causes tuberculosis in humans, is known to have developed resistance to almost all drugs in clinical practice. One of the core second-line treatments for multi-dr...
The two diseases have other similarities too. Tuberculosis is also spread through the air, it mainly affects the lungs, and common symptoms include coughing, fever and fatigue. However, unlike COVID-19, research into vaccines, treatments and diagnostics fortuberculosishas been neglected for years. ...
Lalita Ramakrishnan (University of Washington) and colleagues say that traditionally the answer was thought to lie in the fact that the tuberculosis microbe achieves a TB-specific "dormant" or non-replicating state in an infected person. Because virtually all types of antibiotics act only on replica...