During the quest "Firestarter," V travels to Hansen's base at the EBM Petrochem Stadium in Dogtown to put an end to his operation once and for all. Songbird and V hack into its defense systems, while Alex heads up to Hansen's office. V can choose to activate the Icebreaker here or a...
I personally have foundational disagreements on how World of Warcraft raids are the be-all and end-all of anyone wanting to play their game in a hardcore manner (with item level and ever-increasing stats being so emphasized), and would probably go berserk trying to deal with pithy Ghostcrawler...