Li-Ying, JasonJohn Wiley & Sons, Ltd.R & D ManagementBuonansegna, E., Salomo, S., Maier, A. M., and Li-Ying, J., 2014, "Pharmaceutical New Product Development: Why do Clinical Trials Fail?," R&D Manage., 44(2), pp. 189-202....
However, nine out of ten drug candidates after they have entered clinical studies would fail during phase I, II, III clinical trials and drug approval2,3. It is also worth noting that the 90% failure rate is for the drug candidates that are already advanced to phase I clinical trial, ...
Why did the NHE inhibitor clinical trials fail? Journal of Molecular and Cellular Cardiology. 2008 doi: 10.1016/j.yjmcc. 2008.09.715. in press. [ ... E Murphy,DG Allen - 《Journal of Molecular & Cellular Cardiology》 被引量: 90发表: 2009年 Why did the NHE inhibitor clinical trials fail...
which aggregates and forms tangles in patients' brain tissue and is involved in 75% of all dementias. While tau-targeting drugs have looked promising in mouse models, they've failed in clinical trials.
Why do antioxidants fail to provide clinical benefit? 来自 Semantic Scholar 喜欢 0 阅读量: 29 作者:A Warnholtz,T Münzel 摘要: p pThe results of recent randomized trials to test the influence of antioxidants on coronary-event rates and prognosis in patients with coronary-artery disease were ...
The researchers found that the participants who wrote to-do lists fell asleep an average of 9 minutes faster than those who wrote about already-accomplished tasks. While 9 minutes may not seem like a lot of extra shut-eye, it’s comparable to the improvement seen in clinical trials for some...
Opal S M. Clinical trials of novel therapeutic agents: why did they fail? In: Vincent J L, editor. Yearbook of intensive care and emergency medicine. Berlin, Germany: Springer-Verlag; 1995. pp. 425–436.Opal SM. Clinical trials of novel therapeutic agents: why did they fail? In: ...
Why do pediatric oncologists fail? First, death in children from cancer is a rare event. Second, few prospective trials in the field of pediatric palliative care describe and quantify symptoms during cure-directed care or at the end ... Harris,B M. - 《J Natl Cancer Inst Monogr》 被引量...
So, why did cinaciguat fail? A consistent strong reduction in PWCP was found with cinaciguat, which is considered as the main mechanism to improve symptoms and clinical outcome in acute heart failure.[7]However, with the same dose that reduced wedge pressure by 6 mm in COMPOSE 1, no eff...
will fail in clinical trials with real patients. 将会在临床试验真正的病人时失败 One of the complexities of aggressive tumors 侵略性肿瘤的复杂性之一 is that they can have multiple populations of slightly different cancerous cells. 是它们有多种略有不同的癌细胞 Over time, distinct genetic mutations...