Beyond the recurrent chromosomal abnormalities, a large panel of mutations has been identified and generally comprises eight functional categories: (i) signaling pathways that include genes coding for TK proteins (FLT3, c-KIT, (RAS, PTPN11); (ii) transcription factors (RUNX1, CEBP); (iii) ...
As a result of these characteristics, which can be demonstrated in in vitro systems [52], infected cells entering the long-term HIV population generally have proviruses that are widely distributed in the transcriptionally active areas of the genome. As a group, the proviruses are present in an...