Hematologic malignancies associated with primary mediastinal germ- cell tumors. Ann Intern Med 1985; 102: 603–609. 44 Fujiwara T, Dunn NR, Hogan BLM. Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the loca- lization and survival of primordial...
Adverse health effects associated with radiation exposure have been known for decades, and ionizing radiation exposure has been linked with a broad range of different types of and as well as birth defects, reproductive effects, and diseases of the circulatory, hematologic, and neurologic systems. ...
Invasive fungal infections are important causes of morbidity and mortality especially in immunocompromised patients. While Candida spp., Aspergillus spp. and Cryptococcus neoformans are responsible for the preponderance of invasive fungal infections, other less common fungal pathogens account for a significant...
Like other chemotherapies used in the clinic, this therapeutic strategy would affect organs that are more ‘primed’ for apoptosis like the hematopoietic system, leading to well-characterized secondary effects. However, the clinical experience with myelosuppression lends optimism that hematologic toxicity ...
Methylation studies have shown global and gene-specific hypermethylation in myelodysplastic syndromes, but there seems to be little relation between the degree of demethylation following hypomethylating treatment and hematologic response. The presence of concurrent genomic hypermethylation and ...
Environmental factors may also operate but are likely to be less important. When CLL occurs in Asians it has different features than CLL in persons of predominately European descent. The reason(s) for this is also not understood. We reviewed data on CLL in Asians (mostly Han Chinese but ...
Not every blood transfusion reaction constitutes a hematologic emergency. On the contrary, most of them comprise mild and transient reactions that are self-limiting or can be easily managed by stopping the transfusion and with antihistamine and steroid therapy. Severe reactions, on the other hand, ...
Six SRC TKs are predominantly expressed in blood cells and disruptions of several SRC TKs induce hematologic abnormalities. While the knock-out (KO) of a single Src TK gene is not lethal, the KO of the Src Lyn gene induces a phenotype of lupus syndrome, suggesting its key role in the ...
Further multicenter clinical studies are necessary to confirm the efficacy of the treatment. However, the hormonal modulation is not the subject matter of this paper. 3. Clinical Trials in Ovarian Cancer Currently, there are nine ICIs approved by the FDA for use in cancer treatment. These are ...
Six SRC TKs are predominantly expressed in blood cells and disruptions of several SRC TKs induce hematologic abnormalities. While the knock-out (KO) of a single Src TK gene is not lethal, the KO of the Src Lyn gene induces a phenotype of lupus syndrome, suggesting its key role in the ...