Health Canada strongly encourages investigators to register their trials at ClinicalTrials.gov or WHO ICTRP. In the United States, the registration of clinical studies on sites such as those listed above is mandatory for studies that require approval by the Food and Drug Administration. Furthermore,...
In a proof-of-principle study, we evaluated the use of Capture-XT, a microfluidic lab-on-chip cleanup and pathogen concentration platform to enrich M. tuberculosis bacilli from clinical sputum specimens for downstream DNA extraction and WGS. Three of the four (75%) samples processed by the ...
This study also provides new data regarding the functionality of alternative vacutainers for genetic analysis, as well as the usability of samples that have undergone toxicological analysis, which may be applied to both clinical and forensic settings. If samples are only stored for a period of ...
Introduction The SARS-CoV-2 virus is responsible for a large variety of clinical manifestations affecting the respiratory tract, going from a- or pauci-symptomatic state, to a pneumonia and an acute respiratory distress syndrome. In order to develop effective intervention strategies, several independ...
The authors thank Joe Sonka, who passed away during the study, and his family for providing the sheep and allowing us to perform a long-term clinical trial on their ranch. Author information Authors and Affiliations Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State ...
In neuroscience clinical research, voxel-wise statistical analysis is commonly adopted to unveil local changes between sets of functional PET or MRI quantitative images36. This technique has been successfully translated for small animal imaging37. More recently, voxel-wise analysis of post mortem 3D ...
Next generation sequencing is helping to overcome limitations in organisms less accessible to classical or reverse genetic methods by facilitating whole genome mutational analysis studies. One traditionally intractable group, the Apicomplexa, contains se
The graph shows the results of the anti-schistosomal activity of the selected compounds compared to DMSO (0.625%) and Auranofin (10 μM in 0.625% DMSO), respective negative and positive controls (average of 24 different replicate wells/control). Compounds with activity on both schistosomula ...
Pre-clinical modelling of viral infections has relied on cell cultures that lack 3D structure and the context of lung extracellular matrices. Here, we propose a bioreactor-based, whole-organ lung model of viral infection. The bioreactor takes advantage of an automated system to achieve efficient ...
Physicians may also use clinical experience, a patient's past medical history, and the like when deciding on a diagnosis and treatment. As such, one of skill will appreciate that the particular ranges and measures are merely relative rather than critical to making a diagnosis or planning a ...