The need to address anticoagulant-induced hemorrhagic risk in clinical settings has prompted research into biomaterial coatings capable of directly suppressing clot formation on extracorporeal devices. Examples include the development of heparin-immobilized surfaces to achieve localized anticoagulation21. However,...
The graph shows the results of the anti-schistosomal activity of the selected compounds compared to DMSO (0.625%) and Auranofin (10 μM in 0.625% DMSO), respective negative and positive controls (average of 24 different replicate wells/control). Compounds with activity on both schistosomula ...
The need to address anticoagulant-induced hemorrhagic risk in clinical settings has prompted research into biomaterial coatings capable of directly suppressing clot formation on extracorporeal devices. Examples include the development of heparin-immobilized surfaces to achieve localized anticoagulation21. However,...
2.1. Clinical findings We studied a large consanguineous family from Pakistan showing features of non-inflammatory PSS, segregating as a recessive trait. Affected individuals reported symptoms starting during the second half of the first decade of life, consisting of generalized white scaling, most prom...
Based on the present findings, we proposed that ROBO1 and ROBO2 should be considered as tumour-suppressor genes in MDS and AML. The characteristics of ROBO1 and ROBO2 as tumour-suppressor genes were also observed in the clinical results. The patients with ROBO mutations or low expression ...
Next generation sequencing is helping to overcome limitations in organisms less accessible to classical or reverse genetic methods by facilitating whole genome mutational analysis studies. One traditionally intractable group, the Apicomplexa, contains se
In this study, atmospheric pressure high-resolution scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging (AP-SMALDI MSI) was used for the first time to describe the chemical distribution of the defensive compounds pederin, pseudopederin, and pederon in tissue ...
The strain of the pandemic on the mental health and well-being of parents could have a negative impact on future parenting. Healthcare professionals should not underestimate the potential consequences of declining perinatal mental health and should be vigilant to screen, enquire, and refer. Further ...
The difference in immunogenic response between the Cholvax and Shanchol vaccines of less than 10% was considered of no clinical importance. Since Cholvax is manufactured with the same technology transfer from IVI and have similar composition as Shanchol, we accepted the non-inferiority margin of ...
Because the study was initiated with health-care workers at high risk, it was estimated that 5% of the placebo group (29 participants) and 2% of the vaccine group (11 participants) would have to be infected to demonstrate a clinical efficacy of 60%. If those rates could not be obtained ...